Results: 4

Identification of the targets of hematoporphyrin derivative in lung adenocarcinoma using integrated network analysis

Biol. Res; 52 (), 2019
BACKGROUND: Hematoporphyrin derivative (HPD) has a sensibilization effect in lung adenocarcinoma. This study was conducted to identify the target genes of HPD in lung adenocarcinoma. METHODS: RNA sequencing was performed using the lung adenocarcinoma cell line A549 after no treatment or treatment with X-...

Investigating ego modules and pathways in osteosarcoma by integrating the EgoNet algorithm and pathway analysis

Braz. j. med. biol. res; 50 (2), 2017
Osteosarcoma (OS) is the most common primary bone malignancy, but current therapies are far from effective for all patients. A better understanding of the pathological mechanism of OS may help to achieve new treatments for this tumor. Hence, the objective of this study was to investigate ego modules and ...

Disease association and inter-connectivity analysis of human brain specific co-expressed functional modules

Biol. Res; 48 (), 2015
BACKGROUND: In the recent studies, it is suggested that the analysis of transcriptomic change of functional modules instead of individual genes would be more effective for system-wide identification of cellular functions. This could also provide a new possibility for the better understanding of differenc...