Purpose:
To evaluate the effect of preoperative intravenous chemotherapy with 5-fluorouracil on liver regeneration in an experimental model of major hepatectomy in rats.
Methods:
Wistar rats were divided into two groups of 20 animals each and submitted to 70% hepatectomy 24 h after intravenous injection...
Abstract Purpose To investigate the effects of pine needle extract (PNE) on the expression of proliferating cell nuclear antigen (PCNA) and Ki-67 during liver regeneration induced by 70% partial hepatectomy (PH) in rat. Methods Forty-eight male rats (SD, 7 weeks) had surgery (70% PH). They were randoml...
Proliferación Celular,
Hepatectomía/métodos,
Antígeno Ki-67/efectos adversos,
Antígeno Ki-67/metabolismo,
Regeneración Hepática/efectos de los fármacos,
Índice Mitótico,
Pinus/química,
Extractos Vegetales/farmacología,
Antígeno Nuclear de Célula en Proliferación/efectos de los fármacos,
Antígeno Nuclear de Célula en Proliferación/metabolismo,
Ratas Sprague-Dawley,
Factores de Tiempo
Abstract Purpose: To investigate the effects of capsiate treatment on hepatic hyperplasia in partially hepatectomized rats. Methods: The animals were divided into a Capsiate group (CPH), a Capsiate Post-Partial Hepatectomy group (CPPH) and a Partial Hepatectomy Control group (PH). CPH and CPPH animal...
Alanina Transaminasa/metabolismo,
Fosfatasa Alcalina/metabolismo,
Apoptosis/efectos de los fármacos,
Aspartato Aminotransferasas/metabolismo,
Capsaicina/análogos & derivados,
Capsaicina/farmacología,
Hepatectomía,
Hígado/efectos de los fármacos,
Hígado/enzimología,
Hígado/patología,
Regeneración Hepática/efectos de los fármacos,
Mitosis/efectos de los fármacos,
Ratas Wistar
Abstract Purpose: To investigate thymoquinone, curcumin and a combination of these two drugs were effective or not at the growth of liver. Methods: Forty female Wistar-Albino rats distributed into five groups of eight rats each, control, thymoquinone, curcumin, and thymoquinone/curcumin groups. Pathol...
Antineoplásicos/farmacología,
Antioxidantes/farmacología,
Arginasa/sangre,
Benzoquinonas/farmacología,
Biomarcadores/sangre,
Proliferación Celular,
Ceruloplasmina/análisis,
Curcumina/farmacología,
Hepatectomía/métodos,
Antígeno Ki-67/análisis,
Hígado/patología,
Neoplasias Hepáticas/cirugía,
Regeneración Hepática/efectos de los fármacos,
Trasplante de Hígado,
Óxido Nítrico/sangre,
Ratas Wistar,
Activador de Tejido Plasminógeno/sangre
Abstract Purpose: To determine the effects of propofol and ketamine anesthesia on liver regeneration in rats after partial hepatectomy (PHT). Methods: Male Wistar albino rats were assigned randomly to four groups of 10. Anesthesia was induced and maintained with propofol in groups 1 and 2, and with ket...
Anestésicos Intravenosos/farmacología,
Apoptosis,
Ketamina/farmacología,
Regeneración Hepática/efectos de los fármacos,
Óxido Nítrico Sintasa de Tipo II/metabolismo,
Propofol/farmacología,
Anestésicos Intravenosos/metabolismo,
Factor Apoptótico 1 Activador de Proteasas/metabolismo,
Hepatectomía,
Interleucina-6/sangre,
Interleucina-6/metabolismo,
Ketamina/metabolismo,
Modelos Animales,
Óxido Nítrico Sintasa de Tipo III/metabolismo,
Antígeno Nuclear de Célula en Proliferación/metabolismo,
Propofol/metabolismo,
Distribución Aleatoria,
Ratas Wistar,
Regulación hacia Arriba
Lima, Sonia Oliveira;
Figueiredo, Maria Bernadete Galrão de Almeida;
Santana, Vanessa Rocha de;
Santana, Danillo Primo Andrade;
Nogueira, Matheus de Souza;
Porto, Erick Sobral;
Andrade, Renata Lima Batalha de;
Santos, Jessica Macêdo;
Albuquerque Junior, Ricardo Luiz Cavalcanti de;
Cardoso, Juliana Cordeiro.
Abstract Purpose: To evaluate the effect of aqueous extract of Baccharis trimera leaves on the proliferative capacity of the liver after partial hepatectomy (PH) in rats. Methods: Twenty Wistar rats weighing between 300 and 450g were divided into two groups: control (HP) and test (HP100-rats that recei...
Abstract Purpose: To investigate the effects of lycopene and resveratrol pretreatment on hepatic hyperplasia in partially hepatectomized rats. Methods: The lycopene group and the resveratrol group received 40 mg/kg/day of lycopene or resveratrol, respectively (dissolved in olive oil or in saline soluti...
Antioxidantes/farmacología,
Carotenoides/farmacología,
Hepatectomía/métodos,
Hígado/efectos de los fármacos,
Hígado/cirugía,
Estilbenos/farmacología,
Alanina Transaminasa/sangre,
Apoptosis/efectos de los fármacos,
Aspartato Aminotransferasas/sangre,
Hígado/enzimología,
Hígado/patología,
Regeneración Hepática/efectos de los fármacos,
Índice Mitótico,
Estrés Oxidativo/efectos de los fármacos,
Ratas Wistar,
Reproducibilidad de los Resultados,
Factores de Tiempo,
Resultado del Tratamiento
Figueiredo, Maria Bernadete Galrão de Almeida;
Santana, Vanessa Rocha de;
Nardelli, Maria Júlia;
Nogueira, Matheus de Souza;
Azevedo, Danilo Xavier;
Santana, Danillo Primo Andrade;
Figueiredo, Ana Galrão de Almeida;
Duarte, Ívison Xavier;
Albuquerque Junior, Ricardo Luiz Cavalcanti de;
Lima, Sônia Oliveira.
ABSTRACT PURPOSE: To assess the effect of aqueous extract of Peumus Boldus (AEPB) on the liver proliferative response after parcial hepatectomy of 70% (PH) in rodents. METHODS: Twenty Wistar rats were divided in two groups: AEPB100 (whose rats received 100mg/Kg of AEPB, once a day, orally, in 4 days pr...
Hepatectomía/métodos,
Hepatocitos/efectos de los fármacos,
Regeneración Hepática/efectos de los fármacos,
Hígado/fisiología,
Peumus/química,
Extractos Vegetales/farmacología,
Modelos Animales de Enfermedad,
Hepatocitos/metabolismo,
Hígado/efectos de los fármacos,
Hojas de la Planta/química,
Ratas Wistar
ABSTRACT Background: Different lesions may affect the liver resulting in harmful stimuli. Some therapeutic procedures to treat those injuries depend on liver regeneration to increase functional capacity of this organ. Aim: Evaluate the effects of tranexamic acid on liver regeneration after partial he...
