This study aimed to investigate the effect of baicalein on migration and invasion of human cutaneous squamous cell carcinoma A431 cells. A431 cells were incubated with baicalein with concentrations of 0 (control), 2, 4, 8, 16 and 32 μmol/L, respectively. The cell proliferation...
Western Blotting,
Neoplasias Cutáneas/tratamiento farmacológico,
Apoptosis,
Proliferación Celular/efectos de los fármacos,
Flavanonas/farmacología,
Flavanonas/administración & dosificación,
Carcinoma de Células Escamosas/tratamiento farmacológico,
Movimiento Celular/efectos de los fármacos,
Metaloproteinasa 9 de la Matriz,
Metaloproteinasa 2 de la Matriz,
Factor A de Crecimiento Endotelial Vascular,
Regulación hacia Abajo,
Antineoplásicos/administración & dosificación,
Antineoplásicos/farmacología,
Invasividad Neoplásica,
Línea Celular Tumoral
SUMMARY: Keloid scar is a unique benign fibroproliferative tumor of the human skin. Previously, it was reported that early growth response 1 (EGR1), a transcription factor, promotes keloid fibrosis; however, the mechanism by which EGR1 modulates keloid formation was not elaborated. In this research, the ...
Fibroblastos,
Queloide/patología,
Transfección,
Queloide/genética,
MicroARNs/fisiología,
Proteína 1 de la Respuesta de Crecimiento Precoz,
Apoptosis,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Western Blotting,
Proliferación Celular,
Movimiento Celular,
Regulación hacia Abajo,
d0347410,
Análisis de Secuencia de ARN,
Cicatrización de Heridas
SUMMARY: This study is to investigate the effect of survivin down-regulation by Egr1-survivin shRNA combined with radiotherapy on the apoptosis and radiosensitivity of esophageal squamous cell carcinoma ECA109 and KYSE150 cells. ECA109 and KYSE150 cells were transfected with Egr1-survivin shRNA, and then...
Neoplasias Esofágicas/terapia,
Carcinoma de Células Escamosas de Esófago/terapia,
Neoplasias Esofágicas/genética,
Carcinoma de Células Escamosas de Esófago/genética,
Transfección,
Survivin,
Fármacos Sensibilizantes a Radiaciones,
Neoplasias Esofágicas/radioterapia,
Carcinoma de Células Escamosas de Esófago/radioterapia,
Línea Celular Tumoral/efectos de la radiación,
ARN Mensajero,
Western Blotting,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Regulación hacia Abajo,
Apoptosis,
Citometría de Flujo,
Caspasa 3,
Caspasa 9,
ARN Interferente Pequeño,
Terapia Combinada,
Tolerancia a Radiación,
Proteína 1 de la Respuesta de Crecimiento Precoz
Abstract Although propolis has been reported for having anti-inflammatory activities, its effects on complement system has not been much studied. This research was conducted to find out the effects of Indonesian propolis on the expression levels of C3, C1r/s, Bf, MBL, and C6 in zebrafish larvae which wer...
ABSTRACT Objective: A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) and ADAMTS-5 normal expression levels are essential for ovulation and subsequent fertilization. The objective of the present study was to assess expression pattern of these genes in cumulus cells (CCs) taken ...
The purpose of this study was to investigate the anti-cancer effect of melittin on growth, migration, invasion, and apoptosis of non-small-cell lung cancer (NSCLC) cells. This study also explored the potential anti-cancer mechanism of melittin in NSCLC cells. The results demonstrated that melittin suppre...
Apoptosis,
Factor Apoptótico 1 Activador de Proteasas,
Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico,
Carcinoma de Pulmón de Células no Pequeñas/genética,
Caspasa 3,
Línea Celular Tumoral,
Movimiento Celular,
Regulación hacia Abajo,
Regulación Neoplásica de la Expresión Génica,
Neoplasias Pulmonares/tratamiento farmacológico,
Neoplasias Pulmonares/genética,
Sistema de Señalización de MAP Quinasas,
Meliteno/farmacología,
Invasividad Neoplásica,
Factor de Crecimiento Transformador beta/metabolismo
Patients with osteosarcoma (OS) usually have poor overall survival because of frequent metastasis. Long non-coding RNAs (lncRNAs) have been reported to be associated with tumorigenesis and metastasis. In this study, we investigated the expression and roles of lncRNA human histocompatibility leukocyte ant...
Neoplasias Óseas/genética,
Neoplasias Óseas/patología,
Línea Celular Tumoral,
Movimiento Celular,
Proliferación Celular,
Regulación hacia Abajo,
Regulación Neoplásica de la Expresión Génica,
MicroARNs/metabolismo,
Invasividad Neoplásica,
Osteosarcoma/genética,
Osteosarcoma/patología,
ARN Largo no Codificante/genética,
Receptor EphA7/metabolismo
Osteoarthritis (OA) is a chronic health condition. MicroRNAs (miRs) are critical in chondrocyte apoptosis in OA. We aimed to investigate the mechanism of miR-130b in OA progression. Bone marrow mesenchymal stem cells (BMSCs) and chondrocytes were first extracted. Chondrogenic differentiation of BMSCs was...
ABSTRACT Objective To evaluate the effects of Arf6 downregulation on human prostate cancer cells. Materials and Methods The effects of Arf6 downregulation on cell proliferation, migration, invasion and apoptosis were assessed by MTT, BrdU, scratch, Transwell assays and flow cytometry respectively. AK...
