Antecedentes y Objetivos
La prescripción no médica es una práctica que ha ido en aumento a nivel internacional, abarcando diferentes profesiones de la salud tales como enfermería, obstétrica, farmacéutica, optometría y podología.En este contexto, el Departamento Política y Regulaciones Farmacé...
Abstract Alzheimer's disease is a devastating neurodegenerative disorder characterized by memory loss and cognitive decline. New AD treatments are essential, and drug repositioning is a promising approach. In this study, we combined ligand-based and structure-based approaches to identify potential candid...
Leishmanioses são doenças infecciosas causadas por parasitos do gênero Leishmania, transmitidos por insetos flebotomíneos. A leishmaniose visceral é a forma mais grave e pode ser fatal quando não tratada adequadamente. O tratamento é restrito a poucos fármacos que apresentam limitações em seu u...
A tuberculose (TB) é uma doença infecciosa causada pelo Mycobacterium tuberculosis que apresenta alta morbidade e mortalidade. Atualmente, a tuberculose afeta 9,9 milhões de pessoas em todo o mundo e é responsável por cerca de 1,3 milhões de mortes, sendo um sério problema de Saúde Pública globa...
The antiparasitic niclosamide has shown promising anticancer activity in preclinical studies against several types of cancer, such as colorectal and prostate. Thus, the objective of this work was to develop innovative formulations for the repositioning of niclosamide as an anticancer agent. In chapter I,...
BACKGROUND Treatment of mycoses is often ineffective, usually prolonged, and has some side effects. These facts highlight the importance of discovering new molecules to treat fungal infections. OBJECTIVES To search the Medicines for Malaria Venture COVID Box for drugs with antifungal activity. METHOD...
ABSTRACT Despite the recent developments in modern cataract surgery and the application of a vast array of new devices and machines, late in-the-bag intraocular lens dislocation remains a devastating, albeit rare, complication. Various nonsurgical and surgical techniques have been used to manage this com...
A doença de Chagas (DC), também conhecida como tripanossomíase americana, afeta cerca de 6 a 7 milhões de pessoas em todo o mundo, com aproximadamente 70 milhões de pessoas em áreas de risco. Causada pelo parasita Trypanosoma cruzi, a DC é um problema de saúde pública, ocorrendo do sul dos Estad...
Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious infection that may break the healthcare system of several countries. Here, we aimed at presenting a critical view of ongoing drug repurposing efforts for COVID-19 as well ...
ABSTRACT The World Health Organization (WHO) was informed on December 2019 about a coronavirus pneumonia outbreak in Wuhan, Hubei province (China). Subsequently, on March 12, 2020, 125,048 cases and 4,614 deaths were reported. Coronavirus is an enveloped RNA virus, from the genus Betacoronavirus, that is...
