Results: 7

Brain Tumor Heterogeneity

Belsuzarri, Telmo Augusto Barba; Neves, Maick Willen Fernandes; Costa, Otávio Augusto da; Soares, Diego Alves; Melo Filho, Fernando Antônio de; Guimarães, Mariana Mazzuia; Gonçales, Tiago Fernandes; Zeviani, Wolnei Marques; Araújo, João Flávio Mattos.

Arq. bras. neurocir; 40 (3), 2021

Tumor heterogeneity is the concept that different tumor cells provide distinct biomorphological lesions, gene expressions, proliferation, microenvironment and graduated capacity of metastatic lesions. Brain tumor heterogeneity has been recently discussed about the interesting interaction of chronic infla...

Neoplasias Encefálicas/genética, Heterogeneidad Genética, Evolución Clonal/genética, Células Madre Neoplásicas/citología, Glioma/genética, Nicho de Células Madre/genética, Microambiente Tumoral, Microambiente Celular/genética, Proteínas Tirosina Quinasas Receptoras/genética, Resistencia a Antineoplásicos/genética, Perfilación de la Expresión Génica, RNA-Seq

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Knockdown of long non-coding RNA HOTAIR reverses cisplatin resistance of ovarian cancer cells through inhibiting miR-138-5p-regulated EZH2 and SIRT1

Zhang, Yun; Ai, Hao; Fan, Xue; Chen, Suxian; Wang, Yadi; Liu, Lili.

Biol. Res; 53 (), 2020

BACKGROUND: Cisplatin resistance (DDP-resistance) remains one of the major causes of poor prognosis in females with ovarian cancer. Long non-coding RNAs (lncRNAs) have been shown to participate in the regulation of cellular processes, including chemoresistance. The aim of this study was to explore the ro...

Cisplatino/farmacología, Resistencia a Antineoplásicos/genética, Neoplasias Ováricas/genética, ARN Largo no Codificante/genética, Apoptosis/efectos de los fármacos, Proteína Potenciadora del Homólogo Zeste 2/antagonistas & inhibidores, Regulación Neoplásica de la Expresión Génica/efectos de los fármacos, Técnicas de Inactivación de Genes/métodos, MicroARNs/antagonistas & inhibidores, Sirtuina 1/antagonistas & inhibidores, Línea Celular Tumoral, Reacción en Cadena en Tiempo Real de la Polimerasa, Regulación hacia Arriba

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MicroRNA-4290 suppresses PDK1-mediated glycolysis to enhance the sensitivity of gastric cancer cell to cisplatin

Qian, Yan; Wu, Xu; Wang, Haixiao; Hou, Guowei; Han, Xiao; Song, Wei.

Braz. j. med. biol. res; 53 (5), 2020

The development of chemotherapy resistance significantly impairs the efficiency of chemotherapy, but the underlying mechanisms of chemotherapy resistance in gastric cancer (GC) are complicated and still need to be further explored. Here, we aimed to reveal the effects of miR-4290/PDK1 (pyruvate dehydroge...

Apoptosis/efectos de los fármacos, Línea Celular Tumoral, Proliferación Celular/efectos de los fármacos, Cisplatino/farmacología, Resistencia a Antineoplásicos/genética, Citometría de Flujo, Regulación Neoplásica de la Expresión Génica, Glucólisis/genética, MicroARNs/metabolismo, Piruvato Deshidrogenasa Quinasa Acetil-Transferidora/genética, Piruvato Deshidrogenasa Quinasa Acetil-Transferidora/metabolismo, Reacción en Cadena en Tiempo Real de la Polimerasa, Neoplasias Gástricas/metabolismo, Transfección

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Upregulation of miR-129-5p increases the sensitivity to Taxol through inhibiting HMGB1-mediated cell autophagy in breast cancer MCF-7 cells

Shi, Ying; Gong, Weihua; Lu, Lu; Wang, Yunfeng; Ren, Jingjing.

Braz. j. med. biol. res; 52 (11), 2019

Although Taxol has improved the survival of cancer patients as a first-line chemotherapeutic agent, an increasing number of patients develop resistance to Taxol after prolonged treatment. The potential mechanisms of cancer cell resistance to Taxol are not completely clear. It has been reported that micro...

Antineoplásicos Fitogénicos/metabolismo, Antineoplásicos Fitogénicos/uso terapéutico, Apoptosis/genética, Autofagia/genética, Neoplasias de la Mama/tratamiento farmacológico, Neoplasias de la Mama/genética, Neoplasias de la Mama/metabolismo, Resistencia a Antineoplásicos/genética, Regulación Neoplásica de la Expresión Génica/genética, Proteína HMGB1/genética, Proteína HMGB1/metabolismo, Células MCF-7/metabolismo, MicroARNs/genética, MicroARNs/metabolismo, Paclitaxel/metabolismo, Paclitaxel/uso terapéutico, Regulación hacia Arriba/genética

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Functional and transcriptomic characterization of carboplatin-resistant A2780 ovarian cancer cell line

Viscarra, Tamara; Buchegger, Kurt; Jofre, Ignacio; Riquelme, Ismael; Zanella, Louise; Abanto, Michel; Parker, Alyssa C; Piccolo, Stephen R; Roa, Juan Carlos; Ili, Carmen; Brebi, Priscilla.

Biol. Res; 52 (), 2019

BACKGROUND: Ovarian cancer is a significant cancer-related cause of death in women worldwide. The most used chemotherapeutic regimen is based on carboplatin (CBDCA). However, CBDCA resistance is the main obstacle to a better prognosis. An in vitro drug-resistant cell model would help in the understanding...

Antineoplásicos/farmacología, Carboplatino/farmacología, Resistencia a Antineoplásicos/genética, Regulación Neoplásica de la Expresión Génica/efectos de los fármacos, Neoplasias Ováricas/genética, Transcriptoma/efectos de los fármacos, Muerte Celular/efectos de los fármacos, Muerte Celular/genética, Neoplasias Ováricas/tratamiento farmacológico, Neoplasias Ováricas/patología, Transcriptoma/genética, Línea Celular Tumoral, Fenotipo, Análisis de Secuencia de ARN, Transducción de Señal

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Impacts of cytochrome P450 2D6 (CYP2D6) genetic polymorphism in tamoxifen therapy for breast cancer impactos do polimorfismo genético do citocromo P450 2D6 (CYP2D6) na terapia com tamoxifeno para câncer de mama

Bezerra, Lucas Soares; Santos-Veloso, Marcelo Antônio Oliveira; Bezerra Junior, Natanael da Silva; Fonseca, Lucilia Carvalho da; Sales, Wivianne Lisley Andrade.

Rev. bras. ginecol. obstet; 40 (12), 2018

Abstract Tamoxifen (TMX) is the main drug used both in pre and postmenopausal women as adjuvant treatment for hormone receptor-positive breast cancer. An important barrier to the use of TMXis the development ofdrug resistance causedby molecular processes related to genetic and epigenetic mechanisms, such...

Antineoplásicos Hormonales/uso terapéutico, Neoplasias de la Mama/tratamiento farmacológico, Neoplasias de la Mama/genética, Citocromo P-450 CYP2D6/genética, Resistencia a Antineoplásicos/genética, Polimorfismo Genético, Tamoxifeno/uso terapéutico

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DNA repair pathways and cisplatin resistance: an intimate relationship

Rocha, Clarissa Ribeiro Reily; Silva, Matheus Molina; Quinet, Annabel; Cabral-Neto, Januario Bispo; Menck, Carlos Frederico Martins.

Clinics; 73 (supl.1), 2018

The main goal of chemotherapeutic drugs is to induce massive cell death in tumors. Cisplatin is an antitumor drug widely used to treat several types of cancer. Despite its remarkable efficiency, most tumors show intrinsic or acquired drug resistance. The primary biological target of cisplatin is genomic ...

Antineoplásicos/uso terapéutico, Cisplatino/uso terapéutico, Daño del ADN/efectos de los fármacos, Daño del ADN/genética, Reparación del ADN/genética, Resistencia a Antineoplásicos/genética

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