Background and Objectives: Vancomycin-resistant Enterococcus faecium (VREf) is an opportunistic pathogen responsible for hospital infections, characterized by increasing prevalence and a lack of comprehensive epidemiological studies. We aimed to assess the occurrence of VREf and vancomycin resistance gen...
Introducción: La emergencia y diseminación de la re-sistencia a antimicrobianos está vinculada en parte al abuso y/o mal uso de los mismos. La propagación del SARS-CoV-2 implicó un mayor consumo de antibióticos. El objetivo de este trabajo fue analizar los mecanismos de res...
Introducción. La resistencia de Plasmodium falciparum a diferentes fármacos antipalúdicos es un obstáculo para eliminar la enfermedad. El genotipo resistente de P. falciparum a la artemisinina puede evaluarse examinando los polimorfismos en el dominio de la hélice del gen Pfk13. La Organización Mun...
Background and objectives: colonization by extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae in Intensive Care Unit (ICU) patients is considered a risk factor for infections, and poses as a source of spreading these strains in hospital facilities. This study aimed to perform the genet...
Introducción: Las úlceras de pie diabético tienen una importante morbimortalidad, más aun, si están asociadas a bacterias multirresistentes a los antimicrobianos. Objetivo: Analizar las características de las úlceras de pie diabético infectadas con bacterias multirresistentes a los antimicrobiano...
Silva , Clemente;
Boene, Simone;
Datta , Debayan;
Valbona, Eduard Rovira;
Díaz, Andrés Aranda 3 4;
Cisteró, Pau;
Hathaway , Nicholas;
Tessema, Sofonias;
Chidimatembue, Arlindo;
Matambisso, Glória;
Nhama, Abel;
Macete, Eusebio;
Pujol, Arnau;
Nhamussua , Lidia;
Galatas, Beatriz;
Guinovart, Caterina;
Enosse, Sónia;
Carvalho, Eva;
Rogier, Eric;
Plucinski, ateusz M;
Colborn, James;
Zulliger, Rose;
Saifodine, Abuchahama;
Alonso, Pedro L;
Candrinho , Baltazar;
Greenhouse , Bryan 3;
Saute, Francisco;
Mayor, Alfredo.
Mozambique is one of the four African countries which account for over half of all malaria deaths worldwide, yet little is known about the parasite genetic structure in that country. We performed P. falciparum amplicon and whole genome sequencing on 2251 malaria-infected blood samples collected in 2015 a...
Abstract Plasmodium falciparum resistance to Chloroquine (CQ) is a significant cause of mortality and morbidity worldwide. There is a paucity of documented data on the prevalence of CQ-resistant mutant haplotypes of Pfcrt and Pfmdr1 genes from malaria-endemic war effected Federally Administered Tribal Ar...
Abstract Paclitaxel (PTX) is one of the most effective drugs used in the treatment of breast cancer. Nonetheless, the appearance of MDR1 (multidrug resistance 1) in tumor cells has become a significant hindrance for efficacious chemotherapy. In this study, we show that the expression level of Egr-1 (earl...
Candida auris has been recognized as an emerging multidrug-resistant pathogen with a significant public health burden, causing cases of invasive infection and colonization due to its persistence on inanimate surfaces, ability to colonize skin of some patients, and high transmissibility in healthcare sett...
Honduras presentó datos alarmantes sobre farmacorresistencia (1), que sin lugar a duda debe
servir como base para indagar sobre la situación actual de: (a) efectividad del tratamiento en
pacientes con infección por VIH en el país y sobre (b) la genotipificación y/o fenotipificación de la
resistenci...
