Abstract Plasmodium falciparum resistance to Chloroquine (CQ) is a significant cause of mortality and morbidity worldwide. There is a paucity of documented data on the prevalence of CQ-resistant mutant haplotypes of Pfcrt and Pfmdr1 genes from malaria-endemic war effected Federally Administered Tribal Ar...
Abstract The aim of this study was to characterize the anthelmintic resistance (AR) of a sheep gastrointestinal nematode population, named Caucaia, from northeastern Brazil. Phenotypic tests performed were: egg hatch (EHT), larval development (LDT) and fecal egg count reduction (FECRT). Benzimidazoles (B...
Antihelmínticos/farmacología,
Antihelmínticos/uso terapéutico,
Brasil,
Resistencia a Medicamentos/genética,
Heces,
Haemonchus,
Nematodos,
Recuento de Huevos de Parásitos/veterinaria,
Ovinos,
Enfermedades de las Ovejas/diagnóstico,
Enfermedades de las Ovejas/tratamiento farmacológico
Candidemias caracterizam um grave problema de saúde pública em todo mundo pela alta mortalidade dos casos, onde as espécies apresentam variação epidemiológica e na sensibilidade aos antifúngicos. Objetivou-se demonstrar a frequência de espécies de Candida, enfatizando as espécies crípticas e c...
Abstract INTRODUCTION: Benzimidazoles are commonly used for the control of veterinary nematodes. Resistance to benzimidazoles has been associated with three single nucleotide polymorphisms in the β-tubulin gene of common nematodes. However, these mutations are infrequent in the genus Ascaris spp. ...
Giardiasis is an infectious disease caused by Giardia duodenalis. The pro-drug metronidazole (MTZ) is the first-line treatment for giardiasis. Parasite's proteins as pyruvate:ferredoxin oxidoreductase (PFOR), ferredoxin (Fd), nitroreductase-1 (NR-1) and thioredoxin reductase (TrxR) participate in MTZ act...
Cedillo-Salazar, Félix R;
Martínez-Jacobo, Lizeth;
Pérez-Páramo, Yadira X;
Cerda-Flores, Ricardo;
Martínez, Laura E;
Jaime-Pérez, José C;
Moreno-Treviño, María G;
Pérez-Rodríguez, Edelmiro;
Bosques-Padilla, Francisco J;
Cedillo-Avila, Montserrat;
Cedillo-Avila, María A;
Zamudio-Osuna, Michelle.
abstract Objective: Oral antiplatelet drugs are a key to modern pharmacotherapy in cardiovascular atherothrombotic diseases. Clopidogrel (CLO) constitutes the main preventive treatment of atherothrombosis. However, a considerable inter-individual variation in CLO response has been documented, resulting ...
Alelos,
Enfermedades Cardiovasculares/tratamiento farmacológico,
Enfermedades Cardiovasculares/fisiopatología,
Clopidogrel/administración & dosificación,
Clopidogrel/farmacología,
Citocromo P-450 CYP2C19/genética,
Resistencia a Medicamentos/genética,
México,
Inhibidores de Agregación Plaquetaria/administración & dosificación,
Inhibidores de Agregación Plaquetaria/farmacología,
Polimorfismo de Nucleótido Simple,
Factores de Riesgo
BACKGROUND In addition to the limited therapeutic arsenal and the side effects of antileishmanial agents, drug resistance hinders disease control. In Brazil, Leishmania braziliensis causes atypical (AT) tegumentary leishmaniasis lesions, frequently refractory to treatment. OBJECTIVES The main goal of ...
Abstract INTRODUCTION Mutations in the propeller domain of the Plasmodium falciparum kelch13 (k13) gene are associated with artemisinin resistance. METHODS: We developed a PCR protocol to sequence the pfk13 gene and determined its sequence in a batch of 50 samples collected from 2003 to 2016 in Brazi...
Introducción: La anestesia regional es la más empleada en la cesárea obstétrica. En particular, el uso de la anestesia intratecal tiene sus ventajas. Aunque la tasa de falla es baja, la aparición de este evento genera dificultades que merecen atención.
Objetivo: Describir la conducta anestésica en...
