SUMMARY: Resveratrol (RES) and quercetine (QRC), is a promising agent relevant for both cancer chemoprevention and treatment via several signaling pathways, involved in their anticancer activity related to its chemotherapeutic potential, associated with the induction of ROS generation in cancer cells, le...
SUMMARY: The response of the immune system to harmful stimuli leads to inflammation, and the adverse effects of the toxic hepatitis chemical, thioacetamide (TAA) on the human body are well documented. This article investigated the degree of protection provided by the combined pleotropic drug, metformin (...
Metformina/farmacología,
Resveratrol/farmacología,
Tioacetamida/toxicidad,
Cirrosis Hepática/inducido químicamente,
Serina-Treonina Quinasas TOR,
Inflamación,
Factor de Necrosis Tumoral alfa,
Citocinas/antagonistas & inhibidores,
Sirolimus,
Inmunohistoquímica,
Hígado/efectos de los fármacos,
Inhibidor Tisular de Metaloproteinasa-1,
Cirrosis Hepática/tratamiento farmacológico
SUMMARY: Senile osteoporosis is mainly caused by reduced osteoblast differentiation and has become the leading cause of fractures in the elderly worldwide. Natural organics are emerging as a potential option for the prevention and treatment of osteoporosis. This study was designed to study the effect of ...
Resveratrol/administración & dosificación,
Resveratrol/farmacología,
Osteoporosis/tratamiento farmacológico,
Diferenciación Celular/efectos de los fármacos,
Células Madre Mesenquimatosas/efectos de los fármacos,
Células Madre Mesenquimatosas/citología,
Sirtuina 1,
Modelos Animales de Enfermedad,
Western Blotting,
Ratones Endogámicos C57BL,
Osteogénesis/efectos de los fármacos
Abbas, S R;
Khan, R T;
Shafique, S;
Mumtaz, S;
Khan, A A;
Khan, A M;
Hassan, Z;
Hussain, S A;
Abbas, S;
Abbas, M R;
Batool, A;
Safder, M A.
Abstract By applying the in-silico method, resveratrol was docked on those proteins which are responsible for bone loss. The Molecular docking data between the resveratrol and Receptor activator of nuclear factor-kappa-Β ligand [RANKL] receptors proved that resveratrol binds tightly to the receptors...
SUMMARY: Ingestion of an overdose of paracetamol (also called acetaminophen, or APAP) induces hepatotoxicity that can lead to liver failure. The link between the pro-inflammatory microRNA-155 (miR-155) and leukocyte infiltration (CD45) in APAP- antioxidant depletion and liver toxicity with and without th...
Resumo Fundamento A doxorrubicina (DOX) é frequentemente usada para tratar muitos tipos de cânceres, apesar da cardiotoxicidade dose-dependente. Como alternativa, o resveratrol é um polifenol que tem demonstrado efeitos cardioprotetores em vários modelos de disfunção cardíaca. Objetivo Este estu...
SUMMARY: This study aims to evaluate the ability of resveratrol (RSV) antioxidant to attenuate the oxidative stress condition induced by secondhand exposure of cigarettes and waterpipe smoking using animal model. Forty-eight mice were divided equally into six different groups, and RSV was delivered to ce...
Menezes-Rodrigues, Francisco Sandro;
Errante, Paolo Ruggero;
Araújo, Erisvaldo Amarante;
Fernandes, Mariana Pontes Pacheco;
Silva, Michele Mendes da;
Pires-Oliveira, Marcelo;
Scorza, Carla Alessandra;
Scorza, Fúlvio Alexandre;
Taha, Murched Omar;
Caricati-Neto, Afonso.
ABSTRACT Purpose To evaluate the preventive cardioprotective effects of resveratrol and grape products, such as grape juice and red wine, in animal model of cardiac ischemia and reperfusion. Methods Male Wistar rats orally pretreated for 21-days with resveratrol and grape products were anesthetized and...
Acetaminophen (also called paracetamol, or APAP) induced nephrotoxicity is reported after accidental or intentional ingestion of an overdose of the drug. Renal tubular ultrastructural alterations induced by APAP overdose associated with the induction of biomarkers of kidney injury have not been investiga...
Acetaminofén/toxicidad,
Túbulos Renales/efectos de los fármacos,
Resveratrol/administración & dosificación,
Resveratrol/farmacología,
Quercetina/administración & dosificación,
Quercetina/farmacología,
Modelos Animales de Enfermedad,
Sobredosis de Droga,
Ratas Sprague-Dawley,
Microscopía Electrónica de Transmisión,
Antioxidantes/administración & dosificación,
Antiinflamatorios/administración & dosificación,
Urea/sangre,
Creatinina/sangre,
Túbulos Renales/patología
We sought to determine whether the combined polyphenolic compounds, resveratrol and quercetin can substantially protect against modulation of hepatic biomarkers of apoptosis and survival, p53-Bax axis and B-cell lymphoma 2 (Bcl-2) in an animal model of acetaminophen-induced acute liver injury via the ass...
Acetaminofén/toxicidad,
Apoptosis/efectos de los fármacos,
Enfermedad Hepática Inducida por Sustancias y Drogas/enzimología,
Resveratrol/administración & dosificación,
Resveratrol/farmacología,
Quercetina/administración & dosificación,
Quercetina/farmacología,
Antioxidantes/administración & dosificación,
Antioxidantes/farmacología,
Alanina Transaminasa/análisis,
Aspartato Aminotransferasas/análisis,
Estrés Oxidativo,
Interleucina-1,
Modelos Animales de Enfermedad,
Enfermedad Hepática Crónica Inducida por Sustancias y Drogas/patología,
Biomarcadores
