ABSTRACT Structural imaging of the brain is the most widely used diagnostic tool for investigating neurodegenerative diseases. More advanced structural imaging techniques have been applied to early or prodromic phases, but they are expensive and not widely available. Therefore, it is highly desirable to ...
ABSTRACT The objective of this article was to review the disorganization of inner retinal layers as a biomarker in diabetic macular edema. A systematic search was conducted in PubMed®/MEDLINE®, Cochrane and Embase until August 2021. The keywords used were: "disorganization of inner retinal layers (DRIL...
Revisión Sistemática,
Biomarcadores,
Retina/patología,
Edema Macular/fisiopatología,
Retinopatía Diabética/fisiopatología,
Diabetes Mellitus Tipo 2/complicaciones,
Complicaciones de la Diabetes,
Tomografía de Coherencia Óptica,
Agudeza Visual/fisiología,
Trastornos de la Visión/fisiopatología,
Oclusión de la Vena Retiniana/fisiopatología
ABSTRACT Purpose To evaluate the retinal blood vascular network of the retinographies of patients with different grades of diabetic retinopathy. Methods Ninety Retinographies (MESSIDOR database) were used, with different grades of diabetic retinopathy divided into 4 groups: no retinopathy (n=23), gra...
BACKGROUND: Diabetic retinopathy (DR) is a specific microvascular complication arising from diabetes, and its pathogenesis is not completely understood. tRNA-derived stress-induced RNAs (tiRNAs), a new type of small noncoding RNA generated by specific cleavage of tRNAs, has become a promising target for ...
Diabetes Mellitus/genética,
Diabetes Mellitus/metabolismo,
Diabetes Mellitus/patología,
Retinopatía Diabética/genética,
Retinopatía Diabética/metabolismo,
Retinopatía Diabética/patología,
Células Endoteliales,
Neovascularización Patológica/genética,
Retina/metabolismo,
Retina/patología,
Sirtuina 1/metabolismo
ABSTRACT Purpose: This study was conducted to evaluate visual function and changes in the central macular thickness of patients with unresponsive neovascular age-related macular degeneration who were switched from ranibizumab (Lucentis®) to aflibercept (Eylea®) treatment at 30 months. Methods: This r...
RESUMO A Leucemia Linfocitica Aguda (LLA) é uma doença caracterizada por uma alta taxa de sobrevida, porém o número absoluto de crianças que morrem por ela representa uma grande parcela dos casos de óbitos infantis por câncer. A morbidade decorrente de seu tratamento pode deixar sequelas em pessoa...
BACKGROUND: Peroxisome proliferator-activated receptor alpha (PPARα) is associated with diabetic retinopathy (DR), and the underlying mechanism is still unclear. Aim of this work was to investigate the mechanism of PPARα in DR. METHODS: Human retinal capillary pericytes (HRCPs) were treated with high g...
ADN (Citosina-5-)-Metiltransferasa 1/metabolismo,
Retinopatía Diabética,
PPAR alfa/genética,
Retina/patología,
Apoptosis,
Células Cultivadas,
Metilación de ADN,
Diabetes Mellitus,
Modelos Animales de Enfermedad,
Metilación,
Regiones Promotoras Genéticas,
Retina/citología
ABSTRACT Purpose: Reduction of ganglion cell layer thickness may occur in diabetic patients without retinopathy. The relationships of this preclinical finding with retinal thickness or reduced parafoveal vessel density have not been established. This study investigated the relationships of ganglion cell...
Objective: To compare intraocular pressure (IOP) and macular, retinal nerve fiber layer (RNFL), and ganglion cell layer (GCL) thicknesses in treatment-naive children with attention-deficit/hyperactivity disorder (ADHD), children with ADHD on regular methylphenidate (MPH) treatment for at least 3 months, ...
Análisis de Varianza,
Trastorno por Déficit de Atención con Hiperactividad/patología,
Trastorno por Déficit de Atención con Hiperactividad/fisiopatología,
Estudios de Casos y Controles,
Presión Intraocular/fisiología,
Mácula Lútea/patología,
Fibras Nerviosas/patología,
Valores de Referencia,
Retina/patología,
Células Ganglionares de la Retina/patología,
Tomografía de Coherencia Óptica
