LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

tiRNA-Val promotes angiogenesis via Sirt1-Hif-1α axis in mice with diabetic retinopathy

Xu, Yan; Zou, Haidong; Ding, Qi; Zou, Yuelan; Tang, Chun; Lu, Yuyu; Xu, Xun.

Biol. Res; 55 (), 2022

BACKGROUND: Diabetic retinopathy (DR) is a specific microvascular complication arising from diabetes, and its pathogenesis is not completely understood. tRNA-derived stress-induced RNAs (tiRNAs), a new type of small noncoding RNA generated by specific cleavage of tRNAs, has become a promising target for ...

Diabetes Mellitus/genética, Diabetes Mellitus/metabolismo, Diabetes Mellitus/patología, Retinopatía Diabética/genética, Retinopatía Diabética/metabolismo, Retinopatía Diabética/patología, Células Endoteliales, Neovascularización Patológica/genética, Retina/metabolismo, Retina/patología, Sirtuina 1/metabolismo

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The rs2442598 polymorphism in the ANGPT-2 gene is associated with risk for diabetic retinopathy in patients with type 1 diabetes mellitus in a Brazilian population

Dieter, Cristine; Lemos, Natália Emerim; Corrêa, Nathalia Rodrigues de Faria; Costa, Aline Rodrigues; Canani, Luís Henrique; Crispim, Daisy; Bauer, Andrea Carla.

Arch. endocrinol. metab. (Online); 65 (6), 2021

ABSTRACT Objective: As studies have reported the involvement of angiopoietin-2 (ANGPT-2) in the pathogenesis of diabetic retinopathy (DR), the aim of this study was to investigate the association between the ANGPT-2 rs2442598 polymorphism and DR. Materials and methods: This case-control study comprised...

Angiopoyetina 2/genética, Brasil, Estudios de Casos y Controles, Diabetes Mellitus Tipo 1/genética, Retinopatía Diabética/genética, Frecuencia de los Genes, Predisposición Genética a la Enfermedad, Genotipo, Polimorfismo de Nucleótido Simple

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Association between the RAGE (receptor for advanced glycation end-products) -374T/A gene polymorphism and diabetic retinopathy in T2DM

Tao, Dan; Mai, Xuancheng; Zhang, Tiesong; Mei, Yan.

Rev. Assoc. Med. Bras. (1992, Impr.); 63 (11), 2017

Summary Objective: Interaction between advanced glycation end-products (AGEs) and receptor for AGEs (RAGE) in cells could affect both extracellular and intracellular structure and function, which plays a pivotal role in diabetic microvascular complications. The results from previous epidemiological stud...

Alelos, Diabetes Mellitus Tipo 2/complicaciones, Diabetes Mellitus Tipo 2/genética, Retinopatía Diabética/etiología, Retinopatía Diabética/genética, Predisposición Genética a la Enfermedad, Genotipo, Polimorfismo Genético, Receptor para Productos Finales de Glicación Avanzada, Factores de Riesgo

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Comparisons of serum miRNA expression profiles in patients with diabetic retinopathy and type 2 diabetes mellitus

Ma, Jianping; Wang, Jufang; Liu, Yanfen; Wang, Changyi; Duan, Donghui; Lu, Nanjia; Wang, Kaiyue; Zhang, Lu; Gu, Kaibo; Chen, Sihan; Zhang, Tao; You, Dingyun; Han, Liyuan.

Clinics; 72 (2), 2017

OBJECTIVES: The aim of this study was to compare the expression levels of serum miRNAs in diabetic retinopathy and type 2 diabetes mellitus. METHODS: Serum miRNA expression profiles from diabetic retinopathy cases (type 2 diabetes mellitus patients with diabetic retinopathy) and type 2 diabetes mellitus...

Diabetes Mellitus Tipo 2/sangre, Diabetes Mellitus Tipo 2/genética, Retinopatía Diabética/sangre, Retinopatía Diabética/genética, Perfilación de la Expresión Génica, MicroARNs/sangre, Reacción en Cadena en Tiempo Real de la Polimerasa

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Relação dos polimorfismos funcionais -509C>t e 869T>C no gene do TGFβ1 com a retinopatia e nefropatia diabéticas em pacientes com diabetes mellitus tipo 2

Manica, Michel Broilo; Garcia, Cyntia Fagundes; Santos, Kátia Gonçalves dos.

Rev. AMRIGS; 56 (3), 2012

Introdução: O fator de crescimento transformante beta-1 (TGFβ1) é uma citocina multifuncional que regula a proliferação, a diferenciação e a formação da matriz extracelular de vários tipos de células. Existem evidências de que os polimorfismos -509C>T e 869T>C no gene do TGFβ1 alteram a sua...

Estudios de Casos y Controles, Estudios Transversales, Retinopatía Diabética/etiología, Nefropatías Diabéticas/etiología, Retinopatía Diabética/genética, Nefropatías Diabéticas/genética, Diabetes Mellitus Tipo 2/complicaciones, Predisposición Genética a la Enfermedad/epidemiología, Polimorfismo Genético/genética, Factor de Crecimiento Transformador beta1/genética