LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

tiRNA-Val promotes angiogenesis via Sirt1-Hif-1α axis in mice with diabetic retinopathy

Xu, Yan; Zou, Haidong; Ding, Qi; Zou, Yuelan; Tang, Chun; Lu, Yuyu; Xu, Xun.

Biol. Res; 55 (), 2022

BACKGROUND: Diabetic retinopathy (DR) is a specific microvascular complication arising from diabetes, and its pathogenesis is not completely understood. tRNA-derived stress-induced RNAs (tiRNAs), a new type of small noncoding RNA generated by specific cleavage of tRNAs, has become a promising target for ...

Diabetes Mellitus/genética, Diabetes Mellitus/metabolismo, Diabetes Mellitus/patología, Retinopatía Diabética/genética, Retinopatía Diabética/metabolismo, Retinopatía Diabética/patología, Células Endoteliales, Neovascularización Patológica/genética, Retina/metabolismo, Retina/patología, Sirtuina 1/metabolismo

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Correlation of the aqueous humor total antioxidant capacity, total oxidant status, and levels of IL-6 and VEGF with diabetic retinopathy status

Bozkurt, Erdinç; Çakır, Burçin; Çelik, Erkan; Doğan, Emine; Uçak, Turgay; Alagöz, Gürsoy.

Arq. bras. oftalmol; 82 (2), 2019

ABSTRACT Purpose: We aimed to compare the aqueous humor total oxidant status, total antioxidant capacity, and levels of interleukin-6 and vascular endothelial growth factor between patients with diabetic retinopathy and controls and to correlate these levels with the DR status. Methods: Patients who un...

Antioxidantes/análisis, Antioxidantes/metabolismo, Humor Acuoso/metabolismo, Estudios de Casos y Controles, Cromatografía Líquida de Alta Presión, Retinopatía Diabética/metabolismo, Ensayo de Inmunoadsorción Enzimática, Hemoglobina Glucada/análisis, Interleucina-6/análisis, Estrés Oxidativo, Estudios Prospectivos, Valores de Referencia, Estadísticas no Paramétricas, Factor A de Crecimiento Endotelial Vascular/análisis

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Kaempferol inhibited VEGF and PGF expression and in vitro angiogenesis of HRECs under diabetic-like environment

Xu, XH; Zhao, C; Peng, Q; Xie, P; Liu, QH.

Braz. j. med. biol. res; 50 (3), 2017

Diabetic retinopathy (DR) is one of the common and specific microvascular complications of diabetes. This study aimed to investigate the anti-angiogenic effect of kaempferol and explore its underlying molecular mechanisms. The mRNA expression level of vascular endothelial growth factor (VEGF) and placent...

Movimiento Celular, Proliferación Celular, Retinopatía Diabética/metabolismo, Retinopatía Diabética/patología, Células Endoteliales/efectos de los fármacos, Ensayo de Inmunoadsorción Enzimática, Inmunohistoquímica, Quempferoles/farmacología, Factor de Crecimiento Placentario/antagonistas & inhibidores, Retina/patología, Factor A de Crecimiento Endotelial Vascular/antagonistas & inhibidores

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