SUMMARY: Water metabolism in kidney is critical for organisms living in arid environments. In this study, the kidney structure and the expression of AQP1 and AQP2 in Phrynocephalus vlangalii and Camelus bactrianus were studied. It was found that the Phrynocephalus vlangalii has fewer renal corpuscle but ...
OBJECTIVES: To investigate the efficacy and potential molecular mechanism of Huangkui capsule in combination with leflunomide (HKL) for the treatment of immunoglobulin A nephropathy (IgAN) METHODS: IgAN rat models were constructed by treating rats with bovine serum albumin, lipopolysaccharide, and tetra...
OBJECTIVES: Contrast-induced acute kidney injury (CI-AKI) is an important clinical problem that can be aggravated by diabetes mellitus, a major risk factor. However, heme oxygenase-1 (HO-1), a promising therapeutic target, can exert antioxidant effects against CI-AKI. Thus, we investigated the role of HO...
OBJECTIVES To determine the role of the RBP4/PiC/SIRT3 signaling pathway in the opening of the mitochondria permeability transition pore (mPTP) in offspring rats with hypothyroidism during pregnancy. METHODS Sixty Sprague-Dawley (SD) rats were employed in this study. Pregnancy was deemed successful when...
Bedir, F;
Kocaturk, H;
Turangezli, O;
Sener, E;
Akyuz, S;
Ozgeris, F B;
Dabanlioglu, B;
Suleyman, H;
Altuner, D;
Suleyman, B.
It is known that the combined use of antibiotics, such as isoniazid and rifampicin, in the treatment of tuberculosis causes oxidative kidney damage. The aim of this study was to biochemically and histopathologically investigate the effect of lycopene on oxidative kidney damage due to the administration o...
Un tercio de la población mundial tiene niveles anormalmente altos de presión arterial, hipertensión, responsable de casi el 50% de las muertes por accidente cerebrovascular y enfermedad coronaria. La sensibilidad a la sal es un factor de riesgo para la morbilidad y mortalidad cardiovascular y tambié...
Abstract Purpose To evaluate renal histological changes by stereology and morphometry and analyze the main markers of oxidative stress in rats undergoing natural aging. Methods Seventy two Wistar rats were divided into six groups of 12 rats each, which were euthanized at 3, 6, 9, 12, 18, and 24 months ...
SUMMARY Type 2 diabetes mellitus is an important public health problem, with a significant impact on cardiovascular morbidity and mortality and an important risk factor for chronic kidney disease. Various hypoglycemic therapies have proved to be beneficial to clinical outcomes, while others have failed t...
Compuestos de Bencidrilo/uso terapéutico,
Canagliflozina/uso terapéutico,
Enfermedades Cardiovasculares/etiología,
Enfermedades Cardiovasculares/mortalidad,
Enfermedades Cardiovasculares/prevención & control,
Diabetes Mellitus Tipo 2/complicaciones,
Diabetes Mellitus Tipo 2/tratamiento farmacológico,
Nefropatías Diabéticas/etiología,
Nefropatías Diabéticas/metabolismo,
Nefropatías Diabéticas/prevención & control,
Tasa de Filtración Glomerular,
Glucosa/metabolismo,
Glucósidos/uso terapéutico,
Hipoglucemiantes/farmacología,
Hipoglucemiantes/uso terapéutico,
Riñón/efectos de los fármacos,
Riñón/metabolismo,
Riñón/fisiopatología,
Enfermedades Renales/etiología,
Enfermedades Renales/metabolismo,
Enfermedades Renales/prevención & control,
Transportador 2 de Sodio-Glucosa/farmacología,
Transportador 2 de Sodio-Glucosa/uso terapéutico,
Inhibidores del Cotransportador de Sodio-Glucosa 2/farmacología,
Inhibidores del Cotransportador de Sodio-Glucosa 2/uso terapéutico
Abstract Introduction: It is unclear whether residual renal function (RRF) in dialysis patients can attenuate the metabolic impact of the long 68-hour interdialytic interval, in which water, acid, and electrolyte accumulation occurs. Objective: to evaluate serum electrolyte levels, water balance, and a...
Desequilibrio Ácido-Base/fisiopatología,
Bicarbonatos/sangre,
Calcio/sangre,
Estudios Transversales,
Progresión de la Enfermedad,
Riñón/química,
Riñón/metabolismo,
Riñón/fisiopatología,
Pruebas de Función Renal/métodos,
Fosfatos/sangre,
Potasio/sangre,
Diálisis Renal/efectos adversos,
Insuficiencia Renal/sangre,
Insuficiencia Renal/fisiopatología,
Insuficiencia Renal/terapia,
Insuficiencia Renal/orina,
Sodio/sangre,
Equilibrio Hidroelectrolítico/fisiología,
Aumento de Peso
RESUMEN Con el objetivo de determinar el efecto del consumo de harina de cáscara o harina de pulpa de dos variedades de Solanum tuberosum (papa Yungay y papa Canchán) sobre la acumulación de tejido adiposo, peso de órganos y estrés oxidativo en hígado de ratas realizamos un estudio experimental en ...
Obesidad/tratamiento farmacológico,
Estrés Oxidativo/efectos de los fármacos,
Extractos Vegetales/farmacología,
Solanum tuberosum/química,
Tejido Adiposo/efectos de los fármacos,
Riñón/efectos de los fármacos,
Riñón/metabolismo,
Hígado/efectos de los fármacos,
Hígado/metabolismo,
Tamaño de los Órganos/efectos de los fármacos,
Ratas Sprague-Dawley
