LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Ropivacaine promotes apoptosis of hepatocellular carcinoma cells through damaging mitochondria and activating caspase-3 activity

Wang, Wenting; Zhu, Mingyue; Xu, Zhixin; Li, Wei; Dong, Xu; Chen, Yi; Lin, Bo; Li, Mengsen.

Biol. Res; 52 (), 2019

BACKGROUND: Recent evidences indicated that some local anaesthetic agents played a role in inhibiting the proliferation of cancer cells; Whether ropivacaine is able to promote apoptosis of hepatocellular carcinoma (HCC) cells is still unclear. The aim of this study was to investigate the effect of ropiva...

Anestésicos Locales/farmacología, Apoptosis/efectos de los fármacos, Carcinoma Hepatocelular/patología, Caspasa 3/metabolismo, Neoplasias Hepáticas/patología, Ropivacaína/farmacología, Apoptosis/fisiología, Carcinoma Hepatocelular/metabolismo, Proliferación Celular/efectos de los fármacos, Neoplasias Hepáticas/metabolismo, Mitocondrias/efectos de los fármacos, Transducción de Señal/efectos de los fármacos, Línea Celular Tumoral, Citometría de Flujo, Microscopía Confocal, Microscopía Fluorescente

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Effect of ropivacaine combined with pancuronium on neuromuscular transmission and effectiveness of neostigmine and 4-aminopyridine for blockade reversal: experimental study

BACKGROUND AND OBJECTIVES: The local anesthetic effects on neuromuscular junction and its influence on blockade produced by nondepolarizing neuromuscular blockers are still under-investigated; however, this interaction has been described in experimental studies and in humans. The aim of this study was to...