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Botulinum toxin as a treatment for short bowel syndrome in rats

Marques, Isabela Cristina de Souza; Minto, Stefânia Bovo; Marques, Mariane Quaglio; Ribeiro, Juliana; Moraes, Paola Castro; Sbragia Neto, Lourenço; Garcia, Sérgio Britto.
Acta cir. bras; 34 (7), 2019
Abstract Purpose: The denervation of the intestine with benzalkonium chloride (BAC) reduces mortality and improves weight gain in rats with short bowel syndrome (SBS). Nevertheless, translating these promising findings from bench to bedside is not feasible because BAC promotes peritonitis and irreversib...
Compuestos de Benzalconio/farmacología, Peso Corporal/efectos de los fármacos, Toxinas Botulínicas/farmacología, Desnervación/métodos, Modelos Animales de Enfermedad, Íleon/inervación, Íleon/patología, Yeyuno/inervación, Debilidad Muscular/patología, Ratas Wistar, Síndrome del Intestino Corto/patología, Síndrome del Intestino Corto/cirugía
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The effect of ileocecal valve removal in a model of short bowel syndrome

Soler, Wangles Vasconcellos; Lee, Andre Dong; D'albuquerque, Eugênia Machado Carneiro; Capelozzi, Vera; Albuquerque, Luiz Carneiro; Capelhuchick, Peretz; Lancelotti, Carmem Penteado; Galvão, Flavio Henrique Ferreira.
ABCD (São Paulo, Impr.); 32 (1), 2019
ABSTRACT Background : Short bowel syndrome is a harmful condition that needs experimental research. Aim: To assess the impact of the ileocecal valve removal in a model of short bowel syndrome, in order to investigate the evolution of the colon under this circumstance. Method: Fifteen Wistar rats were...
Biopsia, Peso Corporal, Colon/patología, Colon/cirugía, Modelos Animales de Enfermedad, Válvula Ileocecal/patología, Válvula Ileocecal/cirugía, Mucosa Intestinal/patología, Mucosa Intestinal/cirugía, Intestino Delgado/patología, Intestino Delgado/cirugía, Derivación Yeyunoileal/métodos, Distribución Aleatoria, Ratas Wistar, Reproducibilidad de los Resultados, Síndrome del Intestino Corto/patología, Síndrome del Intestino Corto/cirugía, Factores de Tiempo, Resultado del Tratamiento
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Are there differences in the growth adaptation processes of growing and mature organism models of short bowel syndrome?

Tannuri, Ana Cristina Aoun; Rotondo, Ltalo Geraldo; Barros, Guilherme Garcia; Vaisberg, Victor Van; Mendes-Neto, Cícero; Paes, Vitor Ribeiro; Coelho, Maria Cecilia Mendonça; Gonçalves, Josiane; Serafini, Suellen; Tannuri, Uenis.
Clinics; 73 (), 2018
OBJECTIVES: The purpose of this study was to present an experimental model of short bowel syndrome (SBS) in weaning rats and to compare the adaptative mechanisms of the remaining bowel in weaning rats and adult animals by means of morphometric, histologic and molecular methods. METHODS: Twenty-four wean...
Adaptación Fisiológica, Proliferación Celular, Modelos Animales de Enfermedad, Mucosa Intestinal/patología, Intestinos/patología, Intestinos/cirugía, Ratas Wistar, Síndrome del Intestino Corto/patología
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