LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Differential roles for pathogenicity islands SPI-13 and SPI-8 in the interaction of Salmonella Enteritidis and Salmonella Typhi with murine and human macrophages

Espinoza, Rodrigo A; Silva-Valenzuela, Cecilia A; Amaya, Fernando A; Urrutia, Ítalo M; Contreras, Inés; Santiviago, Carlos A.

Biol. Res; 50 (), 2017

BACKGROUND: Salmonella pathogenicity island (SPI)-13 is conserved in many serovars of S. enterica, including S. Enteritidis, S. Typhimurium and S. Gallinarum. However, it is absent in typhoid serovars such as S. Typhi and Paratyphi A, which carry SPI-8 at the same genomic location. Because the interactio...

Islas Genómicas/fisiología, Macrófagos/microbiología, Infecciones por Salmonella/microbiología, Salmonella enteritidis/genética, Salmonella typhi/genética, Islas Genómicas/genética, Interacciones Microbianas/genética, Análisis de Varianza, Fenómenos Fisiológicos Bacterianos, Supervivencia Celular, Células Cultivadas, Genoma Bacteriano, Muridae, Reacción en Cadena de la Polimerasa, Células RAW 264.7, Serogrupo, Especificidad de la Especie

Fulltext

stg fimbrial operon from S. Typhi STH2370 contributes to association and cell disruption of epithelial and macrophage-like cells

BACKGROUND: Salmonella enterica serovar Typhi (S. Typhi) stg operon, encoding a chaperone/usher fimbria (CU), contributes to an increased adherence to human epithelial cells. However, one report suggests that the presence of the Stg fimbria impairs the monocyte-bacteria association, as deduced by the low...