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Ursodeoxycholic acid induces sarcopenia associated with decreased protein synthesis and autophagic flux

Orozco-Aguilar, Josué; Tacchi, Franco; Aguirre, Francisco; Valero-Breton, Mayalen; Castro-Sepulveda, Mauricio; Simon, Felipe; Cabello-Verrugio, Claudio.
Biol. Res; 56 (), 2023
BACKGROUND: Skeletal muscle generates force and movements and maintains posture. Under pathological conditions, muscle fibers suffer an imbalance in protein synthesis/degradation. This event causes muscle mass loss and decreased strength and muscle function, a syndrome known as sarcopenia. Recently, our ...
Sarcopenia/inducido químicamente, Sarcopenia/patología, Ácido Ursodesoxicólico/metabolismo, Ácido Ursodesoxicólico/farmacología, Troponina I/metabolismo, Proteínas Quinasas S6 Ribosómicas 70-kDa/metabolismo, Músculo Esquelético/metabolismo, Ratones Endogámicos C57BL
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Cholic and deoxycholic acids induce mitochondrial dysfunction, impaired biogenesis and autophagic flux in skeletal muscle cells

Abrigo, Johanna; Olguín, Hugo; Tacchi, Franco; Orozco-Aguilar, Josué; Valero-Breton, Mayalen; Soto, Jorge; Castro-Sepúlveda, Mauricio; Elorza, Alvaro A; Simon, Felipe; Cabello-Verrugio, Claudio.
Biol. Res; 56 (), 2023
BACKGROUND: Skeletal muscle is sensitive to bile acids (BA) because it expresses the TGR5 receptor for BA. Cholic (CA) and deoxycholic (DCA) acids induce a sarcopenia-like phenotype through TGR5-dependent mechanisms. Besides, a mouse model of cholestasis-induced sarcopenia was characterised by increased ...
Colestasis/metabolismo, Colestasis/patología, Sarcopenia/metabolismo, Sarcopenia/patología, Modelos Animales de Enfermedad, Mitocondrias, Fibras Musculares Esqueléticas/metabolismo, Músculo Esquelético/metabolismo
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Puntos de corte y validación de una ecuación antropométrica para estimar la masa muscular, en el estudio de la sarcopenia en población mexicana
Cut-off points and validation of an anthropometric equation to estimate muscle mass in the study of sarcopenia in a Mexican population

Ramírez, Erik; Enríquez-Reyna, María Cristina; Garza-Sepúlveda, Gerardo; Tijerina-Sáenz, Alexandra; Ramos-Peña, Esteban; Gómez de la Garza, Magaly.
Salud pública Méx; 57 (6), 2015
Algoritmos, Antropometría/métodos, Composición Corporal, México/epidemiología, Músculos/patología, Estado Nutricional, Tamaño de los Órganos, Valores de Referencia, Sarcopenia/diagnóstico, Sarcopenia/epidemiología, Sarcopenia/patología
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