Passos, Bruno Goulart;
Rangel, Leonardo da Silva;
Albuquerque, Ricardo Diego Duarte Galhardo de;
Caldas, Gabriel Rocha;
Santos, Marcelo Guerra;
Esteves, Ricardo dos Santos;
Milton, Flora Aparecida;
Neves, Francisco de Assis Rocha;
Ruppelt, Bettina Monika;
Santos, José Augusto Albuquerque dos;
Faria, Robson Xavier;
Rocha, Leandro.
The aim of this work was to evaluate the potential of the essential oil (EO) from Ocotea pulchella leaves as an alternative in the control of schistosomiasis. It was tested O. pulchella EO nanoformulation to assess its activity against adult Biomphalaria glabrata, their spawning and Schistossoma mansoni...
Ocotea/química,
Aceites Volátiles/administración & dosificación,
Aceites Volátiles/química,
Moluscos/efectos de los fármacos,
Esquistosomiasis/prevención & control,
Aceites Volátiles/farmacología,
Control Biológico de Vectores,
Derivados de Alilbenceno/análisis,
Dioxolanos/análisis,
Sesquiterpenos de Germacrano/análisis,
Monoterpenos Bicíclicos/análisis,
Cromatografía de Gases,
Emulsiones/administración & dosificación,
Emulsiones/farmacología,
Interacciones Hidrofóbicas e Hidrofílicas,
Biomphalaria/efectos de los fármacos,
Cercarias/efectos de los fármacos,
Schistosoma mansoni/efectos de los fármacos
Paula-Andrade, Cynthia de;
Coelho, Paulo Ricardo Silva;
Nascimento, Ricardo Aurélio Pinto;
Mota, Pedro Moacyr Pinto Coelho;
Romano-Silva, Marco Aurélio;
Alvarenga, Kevin Augusto Faria de;
Schall, Virgínia Torres;
Pimenta, Denise Nacif;
Coelho, Paulo Marcos Zech;
Oliveira, Edward.
Abstract INTRODUCTION In Brazil, Biomphalaria glabrata, B. tenagophila, and B. straminea are intermediate hosts of Schistosoma mansoni, the etiological agent of schistosomiasis mansoni. Molluscicide use is recommended by the WHO for controlling the transmission of this parasite. Euphorbia milii latex h...
Lopes, Marcela Silva;
Suzuki, Brian Michio;
Pereira, Glaécia Aparecida do Nascimento;
Probst, Alexandra Christina;
Ferreira, Rafaela Salgado;
Oliveira, Júlia Teixeira de;
Tecchio, Kimberly Brito;
Santos, Fabio Vieira dos;
Caffrey, Conor Robert;
Oliveira, Renata Barbosa de.
ABSTRACT In the search for new anti-schistosomal agents, a series of fifteen ortho-nitrobenzyl derivatives was assayed in vitro against both the schistosomulum (somule) and adult forms of Schistosoma mansoni. Compounds 8 and 12 showed significant activity against somules at low micromolar concentrations,...
ABSTRACT INTRODUCTION: Schistosomiasis, a parasitic disease caused by trematode flatworms of the genus Schistosoma, affects more than 200 million people worldwide, and its control is dependent on a single drug, praziquantel. Here, we report the in vitro effect of rotundifolone, a monoterpene isolated f...
Abstract INTRODUCTION: We studied the potential in vitro antischistosomal activity of Cerastes cerastes venom on adult Schistosoma mansoni worms. METHODS: Live specimens of the horned viper snake, C. cerastes were collected from the Aswan Governorate (Egypt). Venom was collected from snakes by manual...
Cricetinae,
Relación Dosis-Respuesta a Droga,
Egipto,
Dosificación Letal Mediana,
Microscopía Electrónica de Rastreo,
Schistosoma mansoni/efectos de los fármacos,
Schistosoma mansoni/ultraestructura,
Esquistosomicidas/aislamiento & purificación,
Esquistosomicidas/farmacología,
Factores de Tiempo,
Venenos de Víboras/farmacología
A partir de po de folhas secas de tomateiro (Lycopersicon esculentum cv. Cereja) foram preparados extratos aquosos e alcoolicos. Por extracao metanolico e precipitacao alcalina, foi obtido um produto que denominamos "glicoalcaloide esteroidal bruto" (GEb), no qual, foi caracterizada a presenca de tomatin...
The action of the ether artemisinin (artemether) on Shistosoma mansoni in mice and the hansters experimentally infected with the LE strain was studied. In mice, the drugs showed high schistosomicidal activity using a single intramuscular dose of 100 mg/Kg/day. By the oral route, this dose showed a low ac...
Genetic crosses between phenotypically resistant and sensitive schistosomes demonstrated that resistance to hycanthone and oxamniquine behaves like a recessive trait, thus suggesting that resistance is due to the lack of some factor. We hypothesized that, in order to kill schistosomes, hycanthone and oxa...
The cercarial glycocalyx and schistosomulum surface contains a number of glycoproteins which are expressed in very variable amounts within a parasite population. Tunicamycin inhibits glycoprotein synthesis of schistosomula if the parasites are incubated for 24hr with the drug (10µg ml[raised to the powe...
