Home > LILACS - Literatura Latinoamericana y del Caribe de Ciencias de la Salud > Search result

Results: 2

miR-139-5p protects septic mice with acute lung injury by inhibiting Toll-like receptor 4/Myeloid differentiation factor 88/Nuclear factor-&mac_kgr; B signaling pathway

Zhang, Xiuxiu; Liu, Xin; Chang, Rui; Li, Yue.
Clinics; 76 (), 2021
OBJECTIVES: To investigate the role of miR-139-5p and the TLR4/MyD88/NF-κB signaling pathway in acute lung injury in septic mice. METHOD: A total of 140 healthy male SPF C57BL/6 mice were divided into seven groups, i.e., Normal, Control, NC, miR-139-5p mimic, miR-139-5p inhibitor, TAK-242, and miR-...
Lesión Pulmonar Aguda/genética, Ratones Endogámicos C57BL, MicroARNs/genética, Factor 88 de Diferenciación Mieloide/genética, Factor 88 de Diferenciación Mieloide/metabolismo, FN-kappa B/metabolismo, Sepsis/genética, Transducción de Señal, Receptor Toll-Like 4/genética, Receptor Toll-Like 4/metabolismo
Fulltext

Candidate genes and pathogenesis investigation for sepsis-related acute respiratory distress syndrome based on gene expression profile

Wang, Min; Yan, Jingjun; He, Xingxing; Zhong, Qiang; Zhan, Chengye; Li, Shusheng.
Biol. Res; 49 (), 2016
BACKGROUND: Acute respiratory distress syndrome (ARDS) is a potentially devastating form of acute inflammatory lung injury as well as a major cause of acute respiratory failure. Although researchers have made significant progresses in elucidating the pathophysiology of this complex syndrome over the year...
Trastornos Respiratorios/genética, Sepsis/complicaciones, Sepsis/genética, Estudios de Asociación Genética, Transcriptoma, Ciclo Celular/genética, Bases de Datos Genéticas, Regulación hacia Abajo, Perfilación de la Expresión Génica, Marcación de Gen, Mapas de Interacción de Proteínas, Factores de Transcripción, Regulación hacia Arriba
Fulltext