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HtrA1 suppresses the growth of pancreatic cancer cells by modulating Notch-1 expression

Cheng, Hao; Zhu, Hao; Cao, Meng; Lu, Chenglin; Bao, Shanhua; Pan, Yiming.
Braz. j. med. biol. res; 52 (1), 2019
Pancreatic cancer is well known to be the most deadly malignancy with the worst survival rate of all cancers. High temperature requirement factor A1 (HtrA1) plays an important role in cancer cell proliferation, migration, apoptosis, and differentiation. This study aimed to explore the function of HtrA1 i...
Apoptosis, Diferenciación Celular, Línea Celular Tumoral, Proliferación Celular, Regulación Neoplásica de la Expresión Génica/genética, Serina Peptidasa A1 que Requiere Temperaturas Altas/genética, Serina Peptidasa A1 que Requiere Temperaturas Altas/metabolismo, Neoplasias Pancreáticas/genética, Neoplasias Pancreáticas/metabolismo, Neoplasias Pancreáticas/patología, Receptor Notch1/genética, Receptor Notch1/metabolismo, Transducción de Señal, Regulación hacia Arriba
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Heterozygous HTRA1 missense mutation in CADASIL-like family disease

Wu, Xiaowei; Li, Changxin; Mao, Jinming; Li, Ling; Liu, Yan; Hou, Yao.
Braz. j. med. biol. res; 51 (5), 2018
The aim of this study was to find related pathogenic genes in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy in (CADASIL)-like patients. The direct sequencing and high-throughput multiplex polymerase chain reaction (PCR) was performed to screen for related gene...
CADASIL/genética, Predisposición Genética a la Enfermedad, Genotipo, Heterocigoto, Serina Peptidasa A1 que Requiere Temperaturas Altas/genética, Reacción en Cadena de la Polimerasa Multiplex, Mutación Missense/genética, Linaje, Polimorfismo de Nucleótido Simple
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