Endogenous and exogenous serotonin, but not sumatriptan, ameliorate seizures and neuroinflammation in the pentylenetetrazole-induced seizure model in rats
Arq. neuropsiquiatr; 80 (1), 2022
ABSTRACT Background: Epilepsy has neuropsychiatric comorbidities such as depression, bipolar disorder, and anxiety. Drugs that target epilepsy may also be useful for its neuropsychiatric comorbidities. Objective: To investigate the effects of serotonergic modulation on pro-inflammatory cytokines and th...
Anticonvulsivantes/efectos adversos, Epilepsia/tratamiento farmacológico, Fluoxetina/efectos adversos, Interleucina-6, Pentilenotetrazol/efectos adversos, Ratas Wistar, Convulsiones/inducido químicamente, Convulsiones/tratamiento farmacológico, Serotonina/efectos adversos, Sumatriptán/efectos adversos, Factor de Necrosis Tumoral alfa