Results: 15

Silenciamiento génico en insectos plaga que afectan la industria agrícola usando ARN de interferencia
Gene silencing in pest insects that affect the agricultural industry using interference RNA

NOVA publ. cient; 20 (3), 2022
Resumen Los insectos plaga, son especies de organismos vivos que en forma constante se encuentran en poblaciones altas, ocasionando daños económicos en los cultivos. Generalmente, suele tratarse de especies puntuales, por lo general, sólo una o dos, que pueden causar gran afectación económica en el ...

Síndrome X frágil: presentación clínica, patología y tratamiento

Gac. méd. Méx; 156 (1), 2020
Resumen El síndrome X frágil es la condición monogenética que produce más casos de autismo y de discapacidad intelectual. La repetición de tripletes CGG (> 200) y su metilación conllevan el silenciamiento del gen FMR1. La proteína FMRP (producto del gen FMR1) interacciona con los ribosomas, co...

Relationship between PI3K/mTOR/RhoA pathway-regulated cytoskeletal rearrangements and phagocytic capacity of macrophages

Braz. j. med. biol. res; 53 (7), 2020
The objective of this study was to investigate the relationship between PI3K/mTOR/RhoA signaling regulated cytoskeletal rearrangements and phagocytic capacity of macrophages. RAW264.7 macrophages were divided into four groups; blank control, negative control, PI3K-RNAi, and mTOR-RNAi. The cytoskeletal ch...

Pioneering studies on monogenic central precocious puberty

ABSTRACT Pubertal timing in humans is determined by complex interactions including hormonal, metabolic, environmental, ethnic, and genetic factors. Central precocious puberty (CPP) is defined as the premature reactivation of the hypothalamic-pituitary-gonadal axis, starting before the ages of 8 and 9 yea...

The pathways of cell cycle regulation in retinoblastoma

Rev. bras. anal. clin; 51 (1), 2019
Retinoblastoma is a childhood ocular tumor often caused by the biallelic inactivation of the RB1 gene affecting children up to 5 years of age. A retinoblastoma protein (pRB), encoded by the tumor suppressor gene RB1, is responsible for the regular progression of the G1 phase to the phase S of the cell cy...

Knock-down the expression of TaH2B-7D using virus-induced gene silencing reduces wheat drought tolerance

Biol. Res; 52 (), 2019
BACKGROUND: Drought is a major abiotic stress affecting global wheat (Triticum aestivum L.) production. Exploration of drought-tolerant genes is essential for the genetic improvement of drought tolerance in wheat. Previous studies have shown that some histone encoding genes are involved in plant drought ...

Inactivation of phoPQ genes attenuates Salmonella Gallinarum biovar Gallinarum to susceptible chickens

Braz. j. microbiol; 49 (3), 2018
Abstract Salmonella Gallinarum is a host-restrict pathogen that causes fowl typhoid, a severe systemic disease that is one of the major concerns to the poultry industry worldwide. When infecting the bird, SG makes use of evasion mechanisms to survive and to replicate within macrophages. In this context, ...

Translatômica aplicada ao descobrimento de alterações moleculares em gliomas

O glioblastoma (GBM) está entre os tipos tumorais mais agressivos e de menor resposta a terapias, o que requer, portanto, uma melhor compreensão sobre o comportamento deste tipo tumoral, auxiliando no desenvolvimento de novos tipos de tratamento para a doença. Atualmente, dados de expressão gênica e...

Alteraciones epigenéticas en leucemia linfoblástica aguda

Resumen: La leucemia linfoblástica aguda (LLA) es el tipo de cáncer más frecuente en niños. Aunque se sabe que las alteraciones genéticas constituyen la base de la etiología de la LLA, se ha demostrado que no son suficientes para el desarrollo leucémico; son necesarias alteraciones adicionales, co...