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Neuroprotective and MAOB inhibitory effects of a series of caffeine-8-thioglycolic acid amides

Kasabova-Angelova, Alexandra; Kondeva-Burdina, Magdalena; Mitkov, Javor; Georgieva, Maya; Tzankova, Virginia; Zlatkov, Alexander.
Braz. J. Pharm. Sci. (Online); 56 (), 2020
The effects of new derivatives of caffeine-8-thioglycolic acid (100 µM) on isolated rat brain synaptosomes, human neuroblastoma cell line SH-SY5Y and human recombinant MAOB enzyme (hMAOB) (1 µM) were evaluated. Most of the compounds, administered alone, didn't show statistically significant neurotoxic ...
Amidas/agonistas, Cafeína/antagonistas & inhibidores, Células/clasificación, Economía, Encéfalo/patología, Fármacos Neuroprotectores/análisis, Glutatión/farmacología, Neuroprotección, Oxidopamina, Supervivencia Celular, Sinaptosomas
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Assessment of neuropharmacological potential of low molecular weight components extracted from Rhinella schneideri toad poison

Baldo, Mateus Amaral; Cunha, Alexandra Olimpio Siqueira; Godoy, Lívea Dornela; Liberato, José Luiz; Yoneda, Juliana Sakamoto; Fornari-Baldo, Elisa Correa; Ciancaglini, Pietro; Santos, Wagner Ferreira dos; Arantes, Eliane Candiani.
J. venom. anim. toxins incl. trop. dis; 25 (), 2019
Studies on toad poison are relevant since they are considered a good source of toxins that act on different biological systems. Among the molecules found in the toad poison, it can be highlighted the cardiotonic heterosides, which have a known mechanism that inhibit Na+/K+-ATPase enzyme. However, these p...
Venenos, Bufo rana, Neuroprotección, Peso Molecular, Anticonvulsivantes, Sinaptosomas, Ácido Glutámico
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