LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

The effects of rapamycin and 3-methyladenine on nitric oxide synthase enzymes in cisplatin-induced neurotoxicity

SUMMARY: The aim of this study was to determine the relationship of autophagy-enhancing rapamycin (RAPA) and autophagy- inhibitor 3-methyladenine (3-MA) with Nitric oxide synthases (NOS) in Cisplatin (CIS)-induced neurotoxicity in rats. Rats were divided into 4 groups (n=10): Control was applied saline, ...

Effects of ICI 182, 780, an ERα and ERβ antagonist, and G-1, a GPER agonist, on autophagy in breast cancer cells

Muler, Mari Luminosa; Antunes, Fernanda; Guarache, Gabriel Cicolin; Oliveira, Rafaela Brito; Ureshino, Rodrigo Portes; Bincoletto, Claudia; Pereira, Gustavo José da Silva; Smaili, Soraya Soubhi.

Einstein (São Paulo, Online); 18 (), 2020

ABSTRACT Objective To investigate if ICI 182,780 (fulvestrant), a selective estrogen receptor alpha/beta (ERα/ERβ) antagonist, and G-1, a selective G-protein-coupled receptor (GPER) agonist, can potentially induce autophagy in breast cancer cell lines MCF-7 and SKBr3, and how G-1 affects cell ...

Análisis de Varianza, Autofagia/efectos de los fármacos, Western Blotting, Neoplasias de la Mama/tratamiento farmacológico, Neoplasias de la Mama/patología, Proliferación Celular/efectos de los fármacos, Supervivencia Celular/efectos de los fármacos, Antagonistas del Receptor de Estrógeno/farmacología, Receptor alfa de Estrógeno/antagonistas & inhibidores, Receptor beta de Estrógeno/antagonistas & inhibidores, Citometría de Flujo/métodos, Fulvestrant/farmacología, Células MCF-7, Receptores Acoplados a Proteínas G/agonistas, Receptores Acoplados a Proteínas G/análisis, Reproducibilidad de los Resultados, Sirolimus/farmacología, Factores de Tiempo, Transfección/métodos

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