SUMMARY: Hypoxic preconditioning is known to induce neuroprotection, but its effects and pathways in chronic brain pathology still unknown. The aim was to establish an involvement of a7 subunit of nicotinic acetylcholine receptors (a7nAchRs), and sirtuins of 1 (SIRT1) and 3 (SIRT3) types in the effects o...
SUMMARY: Senile osteoporosis is mainly caused by reduced osteoblast differentiation and has become the leading cause of fractures in the elderly worldwide. Natural organics are emerging as a potential option for the prevention and treatment of osteoporosis. This study was designed to study the effect of ...
Resveratrol/administración & dosificación,
Resveratrol/farmacología,
Osteoporosis/tratamiento farmacológico,
Diferenciación Celular/efectos de los fármacos,
Células Madre Mesenquimatosas/efectos de los fármacos,
Células Madre Mesenquimatosas/citología,
Sirtuina 1,
Modelos Animales de Enfermedad,
Western Blotting,
Ratones Endogámicos C57BL,
Osteogénesis/efectos de los fármacos
Abstract This study aimed to investigate the role and signaling pathways of β3-AR in myocardial ischemia/reperfusion (I/R) injury, which is one of the leading causes of death worldwide. 47 male rats were randomly divided into two main groups to evaluate infarct size and molecular parameters. Rats in...
BACKGROUND: Diabetic retinopathy (DR) is a specific microvascular complication arising from diabetes, and its pathogenesis is not completely understood. tRNA-derived stress-induced RNAs (tiRNAs), a new type of small noncoding RNA generated by specific cleavage of tRNAs, has become a promising target for ...
Diabetes Mellitus/genética,
Diabetes Mellitus/metabolismo,
Diabetes Mellitus/patología,
Retinopatía Diabética/genética,
Retinopatía Diabética/metabolismo,
Retinopatía Diabética/patología,
Células Endoteliales,
Neovascularización Patológica/genética,
Retina/metabolismo,
Retina/patología,
Sirtuina 1/metabolismo
This study aimed to investigate the value of sirtuin 1 (SIRT1) in differentiating sepsis patients from healthy controls (HCs), and its correlation with inflammation, disease severity, as well as prognosis in sepsis patients. Serum samples were collected from 180 sepsis patients and 180 age- and gender-ma...
Previous research has shown that suppression of miR-383 can prevent inflammation of the endothelium, as well as postpone the development of atherosclerosis. However, the role of miR-383 in endothelial cell apoptosis in diabetes remains unclear. The aim of this study was to investigate the function of miR...
Apoptosis/efectos de los fármacos,
Células Cultivadas,
Endotelio Vascular/citología,
Endotelio Vascular/efectos de los fármacos,
Endotelio Vascular/fisiología,
Glucosa/farmacología,
Ratones Endogámicos C57BL,
MicroARNs/antagonistas & inhibidores,
Estrés Oxidativo/efectos de los fármacos,
Transducción de Señal,
Sirtuina 1/metabolismo
BACKGROUND: Cisplatin resistance (DDP-resistance) remains one of the major causes of poor prognosis in females with ovarian cancer. Long non-coding RNAs (lncRNAs) have been shown to participate in the regulation of cellular processes, including chemoresistance. The aim of this study was to explore the ro...
Cisplatino/farmacología,
Resistencia a Antineoplásicos/genética,
Neoplasias Ováricas/genética,
ARN Largo no Codificante/genética,
Apoptosis/efectos de los fármacos,
Proteína Potenciadora del Homólogo Zeste 2/antagonistas & inhibidores,
Regulación Neoplásica de la Expresión Génica/efectos de los fármacos,
Técnicas de Inactivación de Genes/métodos,
MicroARNs/antagonistas & inhibidores,
Sirtuina 1/antagonistas & inhibidores,
Línea Celular Tumoral,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Regulación hacia Arriba
Testosterone has been demonstrated to antagonize doxorubicin-induced cardiomyocyte senescence. However, whether testosterone prevents the paraquat-induced cardiomyocyte senescence is largely unknown. The detection of SA-β-gal activity was performed using senescence β-gal staining kit and the re...
MicroRNAs play a crucial role in the progression of spinal cord ischemia/reperfusion injury (SCII). The role of miR-448 and SIRT1 in SCII was investigated in this study, to provide further insights into prevention and improvement of this disorder. In this study, expressions of miR-448 and SIRT1 protein w...
Apoptosis,
Western Blotting,
Modelos Animales de Enfermedad,
Regulación hacia Abajo/fisiología,
Citometría de Flujo,
MicroARNs/metabolismo,
Ratas Sprague-Dawley,
Daño por Reperfusión/metabolismo,
Daño por Reperfusión/fisiopatología,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Sirtuina 1/metabolismo,
Isquemia de la Médula Espinal/metabolismo,
Isquemia de la Médula Espinal/fisiopatología,
Transfección,
Regulación hacia Arriba/fisiología
Abstract Sirtuin 1 has an important role in cellular processes, including apoptosis and cellular stress. The purpose of this study was to assess serum sirtuin 1 levels in women with recurrent implantation failure (RIF). In this cross-sectional study, we included 28 women with RIF, 29 healthy women who ha...
