LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Role of ACE2 Gene Expression in Renin Angiotensin System and Its Importance in Covid-19: In Silico Approach

Tas, Sevgi Kalkanli; Kirkik, Duygu; Işik, Mehmet Emirhan; Kalkanli, Nevin; Uzunoglu, Aylin Seher; Uzunoglu, Merve Saide; Altunkanat, Derya; Alragabi, Jalal Mohammed Mohammed; Tanoglu, Alpaslan.

Braz. arch. biol. technol; 63 (), 2020

Abstract We aimed to analyze the expression profile of ACE2 and similar genes with ACE2, predict the number of variations in ACE2, detect the suspected SNPs on ACE2 gene, and perform the pathway analysis of renin-angiotensin system (RAS) and protein absorption-digestion. Moreover, we have predicted the g...

Infecciones por Coronavirus/enzimología, Neumonía Viral/enzimología, Pandemias, Peptidil-Dipeptidasa A/genética, Sistema Renina-Angiotensina/genética, Genotipo, Expresión Génica

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Polymorphisms of the renin-angiotensin system are not associated with overweight and obesity in a general adult population

Lelis, Deborah de Farias; Pereira, Alexandre Costa; Krieger, José Eduardo; Mill, José Geraldo; Santos, Sérgio Henrique Sousa; Baldo, Marcelo Perim.

Arch. endocrinol. metab. (Online); 63 (4), 2019

ABSTRACT Objective The increased prevalence of obesity and associated comorbidities, such as cardiovascular and metabolic diseases, has gained attention worldwide, and the renin-angiotensin system (RAS) has been pointed out as a possible link. Thus, the present study aimed to verify the possible associ...

Distribución por Edad, Angiotensinógeno/genética, Presión Sanguínea, Índice de Masa Corporal, Brasil, Estudios Transversales, Frecuencia de los Genes/genética, Obesidad/genética, Sobrepeso/genética, Peptidil-Dipeptidasa A/genética, Polimorfismo Genético/genética, Sistema Renina-Angiotensina/genética, Distribución por Sexo, Circunferencia de la Cintura

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Association of polymorphisms within the Renin-Angiotensin System with metabolic syndrome in a cohort of Chilean subjects

Herrera, Christian L; Castillo, Wilma; Estrada, Patricia; Mancilla, Bárbara; Reyes, Gerardo; Saavedra, Nicolás; Guzmán, Neftalí; Serón, Pamela; Lanas, Fernando; Salazar, Luis A.

Arch. endocrinol. metab. (Online); 60 (3), 2016

ABSTRACT Objective Metabolic syndrome (MetS) is associated with hypertension, obesity and dyslipidemia. Thus, genetic variants related with these conditions may modulate its development. We evaluated the effect of polymorphisms in the renin-angiotensin system (RAS) on metabolic syndrome risk in a cohort...

Factores de Edad, Angiotensinógeno/genética, Chile, Estudios de Cohortes, Estudios Transversales, Eliminación de Gen, Predisposición Genética a la Enfermedad, Genotipo, Hipertensión/genética, Síndrome Metabólico/genética, Peptidil-Dipeptidasa A/genética, Polimorfismo Genético, Receptor de Angiotensina Tipo 1/genética, Sistema Renina-Angiotensina/genética, Factores Sexuales

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