Abstract Oxazolidine derivatives (OxD) have been described as third-line antibiotics and antitumoral agents. The inclusion complexes based on cyclodextrin could improve the solubility and bioavailability of these compounds. A novel synthetic OxD was used, and its inclusion complexes were based on 2-hydro...
Abstract The aqueous solubility of cefixime trihydrate (a water insoluble drug) using different hydrotropic agents was determined and solid dispersions of cefixime trihydrate were prepared by hydrotropic solubilization technique. The drugs content were determined. The aqueous solubility of v was increase...
Hidroclorothiazida (HTZ) e valsartana (VAL) são fármacos pouco solúveis em meio aquoso e pertencem às classes IV e II do Sistema de Classificação Biofarmacêutica (SCB), respectivamente. O objetivo deste trabalho foi desenvolver um método para avaliar o perfil de dissolução de formas farmacêuti...
Tadalafil, a long-acting PED-5 inhibitor, is commonly used for the treatment of pulmonary arterial hypertension (PAH). However, its efficacy and clinical application are severely limited by the poor water solubility, low bioavailability and a series adverse effects (e.g. headaches, indigestion). In this ...
Abstract Objective This study aimed to analyze the following physicochemical properties: radiopacity, final setting time, calcium release, pH change, solubility, water sorption, porosity, surface morphology, and apatite-forming ability of two calcium silicate-based materials. Material and methods We te...
Compuestos de Aluminio/química,
Análisis de Varianza,
Calcio/química,
Compuestos de Calcio/química,
Fosfatos de Calcio/química,
Combinación de Medicamentos,
Concentración de Iones de Hidrógeno,
Ensayo de Materiales,
Óxidos/química,
Porosidad/efectos de los fármacos,
Valores de Referencia,
Reproducibilidad de los Resultados,
Silicatos/química,
Solubilidad/efectos de los fármacos,
Estadísticas no Paramétricas,
Propiedades de Superficie/efectos de los fármacos,
Factores de Tiempo,
Agua/química
Abstract Lenalidomide (LND) is an anti-cancer drug and an effective derivative of thalidomide used for multiple myeloma therapy. Because of its poor solubility in water, LND is known to cause low oral bioavailability (below 33%), and as a direct consequence of this, the dosing frequency is extended thus ...
ABSTRACT Different solid forms of an active pharmaceutical ingredient can have distinct chemical and physical characteristics. In this work, we studied the solubility and dissolution properties of the described tibolone polymorphic forms (I and II). Both forms were successively recrystallized and charact...
ABSTRACT Formulators face great challenges in adopting systematic approaches for designing self-nanoemulsifying formulations (SNEFs) for different drug categories. In this study, we aimed to build-up an advanced SNEF development framework for weakly basic lipophilic drugs, such as cinnarizine (CN). First...
ABSTRACT Sodium hypochlorite (NaOCl) remains the most used irrigation solution during root canal preparation because of characteristics such as wide-spectrum antimicrobial activity and organic tissue dissolution capacity. However, these solutions can alter dentin composition and there is no consensus on ...
Colágeno/efectos de los fármacos,
Dentina/química,
Dentina/efectos de los fármacos,
Desinfectantes/química,
Concentración de Iones de Hidrógeno,
Inmersión,
Músculos/efectos de los fármacos,
Valores de Referencia,
Irrigantes del Conducto Radicular/química,
Hipoclorito de Sodio/química,
Solubilidad/efectos de los fármacos,
Espectroscopía Infrarroja por Transformada de Fourier,
Propiedades de Superficie/efectos de los fármacos,
Factores de Tiempo
ABSTRACT Azithromycin is a water-insoluble drug, with a very low bioavailability. In order to increase the solubility and dissolution rate, and consequently increase the bioavailability of poorly-soluble drugs (such as azithromycin), various techniques can be applied. One of such techniques is "solid dis...
