MicroRNA-92b augments sorafenib resistance in hepatocellular carcinoma via targeting PTEN to activate PI3K/AKT/mTOR signaling
Braz. j. med. biol. res; 54 (9), 2021
Sorafenib (SOR) resistance is still a significant challenge for the effective treatment of hepatocellular carcinoma (HCC). The mechanism of sorafenib resistance remains unclear. Several microRNAs (miRNAs) have been identified as playing a role in impairing the sensitivity of tumor cells to treatment. We ...
Carcinoma Hepatocelular/tratamiento farmacológico, Carcinoma Hepatocelular/genética, Línea Celular Tumoral, Proliferación Celular, Resistencia a Antineoplásicos, Regulación Neoplásica de la Expresión Génica, Neoplasias Hepáticas/tratamiento farmacológico, Neoplasias Hepáticas/genética, MicroARNs/genética, Fosfohidrolasa PTEN/genética, Fosfatidilinositol 3-Quinasas/metabolismo, Transducción de Señal, Sorafenib/farmacología, Serina-Treonina Quinasas TOR