LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Yin-Yang-1 decreases Fas-induced apoptosis in acute lymphoblastic leukemia under hypoxic conditions: its implications in immune evasion

Martínez-Torres, Estefany; López-Pérez, Tania V.; Morales-Martínez, Mario; Huerta-Yepez, Sara.

Bol. méd. Hosp. Infant. Méx; 77 (4), 2020

Abstract Background: Acute lymphoblastic leukemia (ALL) is an aggressive malignant disease with high prevalence in pediatric patients. It has been shown that the downregulation of Fas expression is correlated with an inadequate response in ALL, although these mechanisms are still not well understood. Se...

Apoptosis/fisiología, Hipoxia de la Célula/fisiología, Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo, Leucemia-Linfoma Linfoblástico de Células Precursoras/metabolismo, Factor de Transcripción YY1/metabolismo, Receptor fas/metabolismo, Caspasa 3/metabolismo, Línea Celular Tumoral, Regulación hacia Abajo, Expresión Génica, Subunidad alfa del Factor 1 Inducible por Hipoxia/genética, Evasión Inmune, Vigilancia Inmunológica, Leucemia-Linfoma Linfoblástico de Células Precursoras/inmunología, Leucemia-Linfoma Linfoblástico de Células Precursoras/patología, Hipoxia Tumoral/fisiología, Factor de Transcripción YY1/genética, Receptor fasFelodipino

Fulltext

Hypoxia inducible factor-1 (HIF-1α) reduced inflammation in spinal cord injury via miR-380-3p/ NLRP3 by Circ 0001723

Li, Xigong; Lou, Xianfeng; Xu, Sanzhong; Du, Junhua; Wu, Junsong.

Biol. Res; 53 (), 2020

BACKGROUND: Spinal cord injury (SCI) is a severe central nervous system trauma. The present study aimed to evaluate the effect of HIF-1α on inflammation in spinal cord injury (SCI) to uncover the molecular mechanisms of anti-inflammation. RESULTS: HIF-1α was reduced in SCI model rats and HIF-1α activa...

Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo, Inflamación/metabolismo, MicroARNs/genética, Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo, ARN Circular/genética, Traumatismos de la Médula Espinal/metabolismo, Citocinas/sangre, Regulación de la Expresión Génica, Ratas Sprague-Dawley

Fulltext

Propranolol inhibits the proliferation, migration and tube formation of hemangioma cells through HIF-1α dependent mechanisms

Chen, YZ; Bai, N; Bi, JH; Liu, XW; Xu, GQ; Zhang, LF; Li, XQ; Huo, R.

Braz. j. med. biol. res; 50 (12), 2017

The aim of this study was to investigate the mechanism of propranolol on the regression of hemangiomas. Propranolol-treated hemangioma tissues were collected and the expression of hypoxia inducible factor-1α (HIF-1α) was examined. We also established HIF-1α overexpression and knockdown hem...

Apoptosis/efectos de los fármacos, Movimiento Celular/efectos de los fármacos, Proliferación Celular/efectos de los fármacos, Hemangioma/tratamiento farmacológico, Hemangioma/metabolismo, Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo, Propranolol/uso terapéutico, Vasodilatadores/uso terapéutico

Fulltext