Elevated serum Activin A in chronic obstructive pulmonary disease with skeletal muscle wasting
Clinics; 74 (), 2019
OBJECTIVE: Muscle wasting contributes to the reduced quality of life and increased mortality in chronic obstructive pulmonary disease (COPD). Muscle atrophy in mice with cachexia was caused by Activin A binding to ActRIIB. The role of circulating Activin A leading to muscle atrophy in COPD remains elusiv...
Activinas/sangre, Activinas/metabolismo, Índice de Masa Corporal, Caquexia/metabolismo, Estudios de Casos y Controles, Subunidades beta de Inhibinas, Músculo Esquelético/fisiopatología, Atrofia Muscular/sangre, Atrofia Muscular/etiología, Atrofia Muscular/metabolismo, Enfermedad Pulmonar Obstructiva Crónica/sangre, Enfermedad Pulmonar Obstructiva Crónica/complicaciones, Factor de Necrosis Tumoral alfa/sangre, Factor de Necrosis Tumoral alfa/metabolismo