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Effects of rocuronium, sugammadex and rocuronium-sugammadex complex on coagulation in rats

Cavalcanti, Ismar Lima; Braga, Estêvão Luiz Carvalho; Verçosa, Nubia; Schanaider, Alberto; Barrucand, Louis; Boer, Hans Donald de; Vane, Luiz.
Rev. bras. anestesiol; 70 (6), 2020
Abstract Background and objectives: Sugammadex is an alternative pharmacological drug capable of reversing neuromuscular blockades without the limitations that are presented by anticholinesterase drugs. Coagulation disorders that are related to treatment with sugammadex were reported. The exact mechanis...
Anestesia/métodos, Anestésicos por Inhalación, Coagulación Sanguínea/efectos de los fármacos, Combinación de Medicamentos, Fibrinógeno/análisis, Isoflurano, Bloqueo Neuromuscular, Fármacos Neuromusculares no Despolarizantes/administración & dosificación, Fármacos Neuromusculares no Despolarizantes/farmacología, Tiempo de Tromboplastina Parcial, Recuento de Plaquetas, Tiempo de Protrombina, Distribución Aleatoria, Ratas Wistar, Rocuronio/administración & dosificación, Rocuronio/farmacología, Sugammadex/administración & dosificación, Sugammadex/farmacología
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Functional respiratory imaging after neostigmine- or sugammadex-enhanced recovery from neuromuscular blockade in the anesthetised rat: a randomised controlled pilot study

Schepens, Tom; Cammu, Guy; Maes, Sabine; Desmedt, Benny; Vos, Wim; Deseure, Kristof.
Rev. bras. anestesiol; 67 (5), 2017
Abstract Objectives Reductions in diaphragm activity are associated with the postoperative development of atelectasis. Neostigmine reversal is also associated with increased atelectasis. We assessed the effects of neostigmine, sugammadex, and spontaneous reversal on regional lung ventilation and airway ...
Periodo de Recuperación de la Anestesia, Inhibidores de la Colinesterasa/farmacología, Pulmón/diagnóstico por imagen, Pulmón/efectos de los fármacos, Pulmón/fisiología, Neostigmina/farmacología, Bloqueo Neuromuscular, Proyectos Piloto, Distribución Aleatoria, Ratas Sprague-Dawley, Respiración/efectos de los fármacos, Sugammadex/farmacología
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Sugammadex versus neostigmine in pediatric patients: a prospective randomized study

Kara, Turhan; Ozbagriacik, Ozgur; Turk, Hacer Sebnem; Isil, Canan Tulay; Gokuc, Ozan; Unsal, Oya; Seyhan, Emrah; Oba, Sibel.
Rev. bras. anestesiol; 64 (6), 2014
Background and objectives: Acetylcholinesterase inhibitors may cause postoperative residual curarization when they are used for reversal of neuromuscular blockade. Sugammadex reverses neuromuscular blockade by chemical encapsulation and is not associated with the side effects that may occur with the use ...
Procedimientos Quirúrgicos Ambulatorios/instrumentación, Sugammadex/farmacología, Neostigmina/farmacología, Bloqueo Neuromuscular, Extubación Traqueal, Estudios Prospectivos, Método Doble Ciego
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