SUMMARY: Spinal cord injury (SCI) usually arises from compression due to traffic accidents and falls, resulting in varying degrees of movement, sensory loss, and possible paralysis. Glabridin (Gla) is a natural compound derived from licorice. It significantly affects drug development and medicine because...
SUMMARY: We evaluated the role and mechanism of acteoside in the regulation of memory impairment induced by chronic unpredictable mild stress (CUMS). CUMS was used to induce depression in rats and the successful establishment of CUMS model were verified by forced swimming test and sucrose preference test...
Estrés Psicológico/complicaciones,
Trastornos de la Memoria/tratamiento farmacológico,
Glucósidos/administración & dosificación,
Glucósidos/uso terapéutico,
Polifenoles/administración & dosificación,
Polifenoles/uso terapéutico,
Reconocimiento en Psicología/efectos de los fármacos,
Plasticidad Neuronal/efectos de los fármacos,
Serina-Treonina Quinasas TOR/antagonistas & inhibidores,
Depresión/tratamiento farmacológico,
Modelos Animales de Enfermedad,
Ratas Sprague-Dawley,
Escala de Evaluación de la Conducta,
Neuronas,
Técnica del Anticuerpo Fluorescente,
Western Blotting,
Aprendizaje por Laberinto,
Inhibidores mTOR
SUMMARY: Telocytes are a cell population described in 2011 with a multitude of functions such as tissue support, regulation of stem cell niches or intercellular signal transmission. However, there are no studies about their embryonic origin, their function in development, or their moment of appearance. T...
SUMMARY: Changes in the microcirculation of multiple tissues and organs have been implicated as a possible mechanism in physiological aging. In particular, vascular endothelial growth factor is a secretory protein responsible for regulating angiogenesis via altering endothelial proliferation, survival, m...
Vasos Coronarios/fisiología,
Riñón/fisiología,
Riñón/irrigación sanguínea,
Microcirculación,
Envejecimiento,
Factores de Crecimiento Endotelial Vascular/metabolismo,
Capilares/anatomía & histología,
Vasos Coronarios/anatomía & histología,
Riñón/anatomía & histología,
Corazón/anatomía & histología,
Corazón/fisiología,
Inmunohistoquímica,
Técnica del Anticuerpo Fluorescente,
Ratas Wistar
SUMMARY: Gastrin plays a vital role in the development and progression of gastric cancer (GC). Its expression is up-regulated in GC tissues and several GC cell lines. Yet, the underlying mechanism remains to be investigated. Here, we aim to investigate the role and mechanism of gastrin in GC proliferatio...
Gastrinas/metabolismo,
Neoplasias Gástricas/metabolismo,
Neoplasias Gástricas/patología,
Apoptosis,
Especies Reactivas de Oxígeno,
Anexina A2/metabolismo,
Proliferación Celular,
FN-kappa B,
Mitocondrias/patología,
Citometría de Flujo,
Técnica del Anticuerpo Fluorescente,
Espectrometría de Masas,
Línea Celular Tumoral,
Inmunoprecipitación,
Carcinogénesis
SUMMARY: The skin, located on the outermost part of the body, is always exposed to external stimuli such as sunlight. The exposure of skin to ultraviolet B (UVB) radiation from sunlight is known to be a major environmental factor in inducing photoaging. After exposure to UVB, an increase in reactive oxyg...
Abstract Objectives The capsuloligamentous structures of the shoulder work as static stabilizers, together with the biceps and rotator cuff muscles, increasing the contact surface of the glenoid cavity. Free nerve endings and mechanoreceptors have been identified in the shoulder; however, there are a fe...
Cisplatin, the first platinum compound approved for cancer treatment, is widely used in the treatment of various cancers including hepatocellular carcinoma (HCC). HCC incidence rates rise globally. Epithelial mesenchymal transition (EMT) is implicated in cancer invasion and metastasis, which are associat...
Cisplatino/administración & dosificación,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Microscopía Confocal,
Células Cultivadas,
Antineoplásicos/administración & dosificación,
Cadherinas/efectos de los fármacos,
Cadherinas/genética,
Vimentina/efectos de los fármacos,
Vimentina/genética,
Factores de Transcripción de la Familia Snail/efectos de los fármacos,
Factores de Transcripción de la Familia Snail/genética,
Técnica del Anticuerpo Fluorescente,
Cadherinas/metabolismo,
Vimentina/metabolismo,
Factores de Transcripción de la Familia Snail/metabolismo,
Células Hep G2,
Invasividad Neoplásica,
Transición Epitelial-Mesenquimal
SUMMARY: Carnosine is known as a natural dipeptide, which inhibits the proliferation of tumor cells throughout its action on mitochondrial respiration and cell glycolysis. However, not much is known about its effects on the metabolism of healthy cells. We explored the effects of Karnozin EXTRA® capsule ...
Carnosina/farmacología,
Fibroblastos/efectos de los fármacos,
Riñón/citología,
Supervivencia Celular/efectos de los fármacos,
Metabolismo Energético,
Vimentina/efectos de los fármacos,
Superóxido Dismutasa/efectos de los fármacos,
Técnicas de Cultivo de Célula,
Bioensayo,
Técnica del Anticuerpo Fluorescente,
Cricetinae
Li, Tian;
Liu, Shuaishuai;
Abula, Zulipiya;
kadier, Kedireya;
Guo, Yanli;
Gu, Simeng;
Wang, Lifeng;
Zhang, Fang;
Mao, Xinmin;
Li, Xuejun.
SUMMARY: Coreopsis tinctoria Nutt. (C. tinctoria Nutt.) can protect diabetic kidneys, but the mechanisms are unclear. This work is to investigate the potential mechanisms of C. tinctoria Nutt. in the treatment of diabetic nephropathy based on network pharmacology analysis of its active ingredients. Twelv...
