Effects of experimental conditions on solubility measurements for BCS classification in order to improve the biowaiver guidelines
Braz. J. Pharm. Sci. (Online); 57 (), 2021
Among the methods described for determining the solubility, shake-flask is suitable to evaluate the equilibrium solubility according to the BCS. Nevertheless, experimental conditions related to the shake-flask method are not well described. Evaluating the effects of experimental conditions on solubility ...