Knockdown of ubiquitin-specific peptidase 39 inhibited the growth of osteosarcoma cells and induced apoptosis in vitro
Biol. Res; 50 (), 2017
BACKGROUND: Ubiquitin specific peptidase 39 (USP39), an essential factor in the assembly of the mature spliceosome complex, has an aberrant expression in several cancer. However, its function and the corresponding mechanism on human osteosarcoma has not been fully explored yet. METHODS: The mRNA and DNA ...
Apoptosis, Técnicas de Silenciamiento del Gen/métodos, Osteosarcoma/enzimología, Osteosarcoma/patología, Proteasas Ubiquitina-Específicas/metabolismo, Proteasas Ubiquitina-Específicas/genética, Línea Celular Tumoral, Proliferación Celular, Citometría de Flujo, Regulación Neoplásica de la Expresión Génica, Vectores Genéticos, Lentivirus, Ensayo de Tumor de Célula Madre