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Localization of Diacylglycerol Kinase ζ in the Kidney of Adult Rats: Its Dominant Expression in Collecting Tubules and its Selective Lack in Proximal Tubules

Hemha, Premrudee; Chomphoo, Surang; Polsan, Yada; Goto, Kaoru; Kondo, Hisatake; Hipkaeo, Wiphawi.
Int. j. morphol; 41 (3), 2023
SUMMARY: Diacylglycerol kinase (DGK) exerts balancing the intracellular level between two-second messengers, diacylglycerol and phosphatidic acid, by its phosphorylation activity. DGK ζ is often localized in cell nuclei, suggesting its involvement in the regulation of intranuclear activities, includ...
Diacilglicerol Quinasa/metabolismo, Túbulos Renales/metabolismo, Ratas Sprague-Dawley, Inmunohistoquímica, Microscopía Inmunoelectrónica, Diacilglicerol Quinasa/ultraestructura, Túbulos Renales/ultraestructura
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Evaluation of TGF-beta1 and MCP-1 expression and tubulointerstitial fibrosis in children with Henoch-Schönlein purpura nephritis and IgA nephropathy: A clinical correlation

Shuiai, Zhao; Huijun, Shen; Weizhong, Gu; Aimin, Liu; Jianhua, Mao.
Clinics; 72 (2), 2017
OBJECTIVES: Henoch-Schönlein purpura nephritis and immunoglobulin A nephropathy are two diseases with similar clinical presentations but very different prognoses. Transforming growth factor β1 and monocyte chemoattractant protein-1 have been associated with the development of tissue fibrosis. We ex...
Quimiocina CCL2/metabolismo, Fibrosis, Glomerulonefritis por IGA/metabolismo, Glomerulonefritis por IGA/patología, Túbulos Renales/metabolismo, Túbulos Renales/patología, Pronóstico, Vasculitis por IgA/metabolismo, Vasculitis por IgA/patología, Factor de Crecimiento Transformador beta1/metabolismo
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Serum concentrations and renal expressions of IL-1 and TNF-a early after hemorrhage in rats under the effect of glibenclamide

Marques, Christiane D'Oliveira; Diego, Luis Antonio dos Santos; Marcondes-Machado, Jussara; Amorim, Renée Lauffer; Carvalho, Lídia Raquel; Módolo, Norma Sueli Pinheiro; Braz, Leandro Gobbo; Castiglia, Yara Marcondes Machado.
Acta cir. bras; 31 (7), 2016
ABSTRACT PURPOSE: To investigate changes in the serum concentration and renal expression of IL-1 and TNF-α cytokines in rats that received sevoflurane and glibenclamide prior to hemorrhage. METHODS: Two groups of sevoflurane-anesthetized Wistar rats (n=10): G1 (control) and G2 (glibenclamide, 1 Â...
Gliburida/farmacología, Hipoglucemiantes/farmacología, Interleucina-1/metabolismo, Riñón/efectos de los fármacos, Choque Hemorrágico/metabolismo, Factor de Necrosis Tumoral alfa/metabolismo, Anestésicos por Inhalación/administración & dosificación, Peso Corporal/efectos de los fármacos, Canales KATP/antagonistas & inhibidores, Riñón/irrigación sanguínea, Riñón/metabolismo, Túbulos Renales/efectos de los fármacos, Túbulos Renales/metabolismo, Éteres Metílicos/administración & dosificación, Modelos Animales, Distribución Aleatoria, Ratas Wistar
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