LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

A study on the toxic effect of different doses of diclofenac sodium on the development of the kidney in the postnatal period

Mustafa, Hesham N; Alkan, Isinsu; Deniz, Ömür Gülsüm; Altunkaynak, Berrin Zuhal; Annaç, Ebru; Kaplan, Suleyman.

Int. j. morphol; 37 (3), 2019

The toxic effects of different doses of diclofenac sodium (DS) on the kidney on the postnatal period (0-7 days) by morphometrical and immunohistochemical methods were investigated. For this purpose, 15 female adult wistar albino rats were used and divided into 5 main groups. Group Ia served as normal con...

Diclofenaco/toxicidad, Diclofenaco/administración & dosificación, Riñón/efectos de los fármacos, Riñón/crecimiento & desarrollo, Apoptosis/efectos de los fármacos, Animales Recién Nacidos, Túbulos Renales Proximales/efectos de los fármacos, Inmunohistoquímica, Ratas Wistar, Coloración y Etiquetado

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Impact of gender in early structural changes of contrast induced nephropathy in rats

Abstract Introduction: Contrast-induced nephropathy (CIN) is a major iatrogenic cause of acute kidney injury. Experimental studies have shown that intravascular injection causes intense vacuolization of the contrast agent in the proximal renal tubules cells, preceding the increase in serum creatinine, a...