Results: 2

Beta Lapachone blocks the cell cycle and induces apoptosis in canine osteosarcoma cells

Cruz, Vanessa S; Rodrigues, Fernanda A; Braga, Karla M. S; Machado, Patrícia A; Bianchi Filho, Cesario; Prado, Yandra C. L; Araújo, Eugênio G.

Pesqui. vet. bras; 38 (12), 2018

Osteosarcoma is a malignant tumor of primitive bone cells with a high incidence in dogs and humans. The need for more effective drugs with less adverse consequences has pushed the development of chemotherapeutic agents from plants and other natural sources. The aim of this study was to verify the cytotox...

Tabebuia/química, Osteosarcoma/veterinaria, Apoptosis, Naftoquinonas

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Reduction of doxorubicin-induced genotoxicity by Handroanthus impetiginosus in mouse bone marrow revealed by micronucleus assay

Boriollo, M F G; Silva, T A; Rodrigues-Netto, M F; Silva, J J; Marques, M B; Dias, C T S; Höfling, J F; Resck, M C C; Oliveira, N M S.

Braz. j. biol; 78 (1), 2018

Abstract Handroanthus impetiginosus has long been used in traditional medicine and various studies have determined the presence of bioactive chemical compounds and potential phytotherapeutics. In this study, the genotoxicity of the lyophilized tincture of H. impetiginosus bark (THI) was evaluated in mous...

Células de la Médula Ósea/citología, Células de la Médula Ósea/efectos de los fármacos, Células Cultivadas, Daño del ADN/efectos de los fármacos, Doxorrubicina/toxicidad, Pruebas de Micronúcleos, Extractos Vegetales/farmacología, Sustancias Protectoras/farmacología, Tabebuia/química

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