LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Development, physicochemical evaluation, and in vivo permeation studies of topical formulations containing 0.1% tacrolimus

Oliveira, Mariana Villas Bôas Vidal de; Alves, Priscila Elias; Teixeira, Jessica; Monteiro, Mariana Sato de Souza de Bustamante; Moreira, Tailane SantAnna; Ricci Junior, Eduardo; Santos, Elisabete Pereira dos; Santos-Oliveira, Ralph; Marins, Rita de Cássia Elias Estrela; Freitas, Zaida Maria Faria de.

Braz. J. Pharm. Sci. (Online); 59 (), 2023

Abstract The objective of this paper was to develop and evaluate two semi-solid pharmaceutical forms containing 0.1% tacrolimus: cream (CRT01) and gel (GLT01). For the evaluation of physicochemical stability, at times 0, 30, 60 and 90 days, at 23°C and at 40°C, High Performance Liquid Chromatography co...

Tacrolimus/agonistas, Absorción Fisiológica/efectos de los fármacos, Cromatografía Líquida de Alta Presión/métodos, Dermatitis Atópica/patología, Enfermedad/clasificación, d0234210, d0103610, Preparaciones Farmacéuticas/análisis, Química Física/clasificación, Pomadas/análisis

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Prediction of the Impact of CYP2C19 Polymorphism on Drug-Drug Interaction between Voriconazole and Tacrolimus Using Physiologically-Based Pharmacokinetic Modelling

Abstract Voriconazole increases tacrolimus blood concentration significantly when coadministrated. The recommendation of reducing tacrolimus to 1/3 in voriconazole package insert seems not to be satisfactory in clinical practice. In vitro studies demonstrated that the magnitude of inhibition depends on t...