Abstract Peripheral nerve damage is an important cause of seeking medical attention. It occurs when the continuity of structures is interrupted and the propagation of nervous impulses is blocked, affecting the functional capacity of individuals. To assess the effects of the immunosuppressants tacrolimus ...
Mucous membrane pemphigoid (MMP) is a blistering disease that predominantly involves the mucous membranes and that can lead to major negative impacts on patient quality of life. The first-line MMP treatment is based on the use of topical and systemic corticosteroids. In this report, we presented a 45-yea...
ABSTRACT BACKGROUND: Immunosuppressive drugs have important role in transplant of solid grafts, it aim avoid episodes of acute and chronic rejection and improving graft survival and patient survival. In Brazil, in 2016, liver transplantation was the third most frequent, with 1,880 transplants performed...
ABSTRACT The authors present a case of lupus miliaris disseminatus faciei , a rare skin disease of unknown etiology, which may cause unaesthetic scarring due to its difficult treatment. The histopathological examination of epithelioid granulomas with caseating necrosis, together with the clinical feature...
Dermatosis Facial/patología,
Dermatosis Facial/tratamiento farmacológico,
Rosácea/patología,
Rosácea/tratamiento farmacológico,
Granuloma/patología,
Granuloma/tratamiento farmacológico,
Enfermedades de los Párpados/patología,
Enfermedades de los Párpados/tratamiento farmacológico,
Lupus Vulgar/patología,
Lupus Vulgar/tratamiento farmacológico,
Cicatriz,
Tetraciclina/uso terapéutico,
Isotretinoína/uso terapéutico,
Dapsona/uso terapéutico,
Tacrolimus/uso terapéutico,
Prednisona/uso terapéutico,
Minociclina/uso terapéutico
Tacrolimus (TAC), a calcineurin inhibitor, and everolimus (EVL), an mTOR inhibitor, have been used as immunosuppressive (ISS) drugs in post-kidney transplantation therapy. The objective of this study was to compare the efficacy of EVL vs TAC in the ISS maintenance triple therapy. Ninety-seven kidney tran...
O Informe Diário de Evidências é uma produção do Ministério da Saúde que tem como objetivo acompanhar diariamente as publicações científicas sobre tratamento farmacológico e vacinas para a COVID-19. Dessa forma, são realizadas buscas estruturadas em bases de dados biomédicas, referentes ao d...
Infecciones por Coronavirus/tratamiento farmacológico,
Neumonía Viral/tratamiento farmacológico,
Betacoronavirus/efectos de los fármacos,
Corticoesteroides/uso terapéutico,
Ribavirina/uso terapéutico,
Células Madre Mesenquimatosas,
Hidroxicloroquina/uso terapéutico,
Ácido Micofenólico/uso terapéutico,
Tacrolimus/uso terapéutico,
Prednisolona/uso terapéutico,
Meropenem/uso terapéutico,
Combinación Trimetoprim y Sulfametoxazol/uso terapéutico,
Ácido Fólico/uso terapéutico,
Ácido Ursodesoxicólico/uso terapéutico,
Lopinavir/uso terapéutico,
Ritonavir/uso terapéutico,
Cloroquina/uso terapéutico,
Interferón-alfa/uso terapéutico,
Azitromicina/uso terapéutico,
Inmunoglobulinas/uso terapéutico,
Anticuerpos Monoclonales/uso terapéutico,
Anticuerpos Neutralizantes/uso terapéutico,
Evaluación de la Tecnología Biomédica,
Estudios de Cohortes,
Estudios Transversales
OBJECTIVES: Here, we aimed to compare the clinical effects of mycophenolate mofetil combined with either tacrolimus or with cyclophosphamide on lupus nephritis (LN) and to analyze their influence on the expression of cystatin C and on transforming growth factor-1 (TGF-β1). METHODS: A total of 234 p...
RESUMO Os polimorfismos genéticos do CYP3A5 têm sido apontados enquanto fatores influenciadores na eficácia farmacológica com tacrolimo em pacientes em terapia imunossupressora no pós-transplante hepático. O presente estudo objetiva realizar uma revisão da literatura acerca da influência dos poli...
This work is aimed at studying the problems of timely diagnostics and therapy of various forms of rosacea, identifying the factors that influence the compliance, prognosis, and quality of life of the patients, as well as the stages of combination therapy. The efficiency of rosacea therapy is determined b...
Abstract BACKGROUND: Tacrolimus, for its activity on modulation of collagen production and fibroblast activity, may have a role in the prevention of hypertrophic scars. OBJECTIVES: Evaluate macroscopic, microscopic, metabolic, laboratory effects and side effects of the use of topical tacrolimus ointmen...
Administración Tópica,
Alanina Transaminasa/sangre,
Alanina Transaminasa/efectos de los fármacos,
Inhibidores de la Calcineurina/administración & dosificación,
Inhibidores de la Calcineurina/farmacología,
Inhibidores de la Calcineurina/uso terapéutico,
Cicatriz Hipertrófica/patología,
Cicatriz Hipertrófica/prevención & control,
Creatinina/sangre,
Modelos Animales de Enfermedad,
Oído Externo/patología,
Eritema/patología,
Inflamación/patología,
Inflamación/prevención & control,
Recuento de Linfocitos,
Pomadas,
Albúmina Sérica/análisis,
Albúmina Sérica/efectos de los fármacos,
Tacrolimus/administración & dosificación,
Tacrolimus/farmacología,
Tacrolimus/uso terapéutico,
Urea/sangre
