Tadalafil-loaded PLGA microspheres for pulmonary administration: preparation and evaluation
Braz. J. Pharm. Sci. (Online); 55 (), 2019
Tadalafil, a long-acting PED-5 inhibitor, is commonly used for the treatment of pulmonary arterial hypertension (PAH). However, its efficacy and clinical application are severely limited by the poor water solubility, low bioavailability and a series adverse effects (e.g. headaches, indigestion). In this ...