Arthritis is positively associated with the decline of sex hormones, especially estrogen. Tamoxifen (TMX) is a selective estrogen receptor modulator, possessing agonist or antagonistic activity in different tissues. Thus, the objective of this study was to investigate the effect of TMX on the zymosan-ind...
Tamoxifen (Tmf), is a standard of care for women with estrogen receptor positive (ER+) breast cancer. Endoxifen is a Tmf metabolite generated by cytochrome P450 2D6 (CYP2D6). Antidepressive agents (AD) are often prescribed to women with breast cancer not only for depression, but also for anxiety and hot ...
Tamoxifen (TAM) is an antiestrogenic drug widely used in breast cancer treatment. By using the Differential Display technique in normal and malignant breast tissues, before and during TAM therapy, we were able to demonstrate that expression of the CD36 gene is down-regulated by this drug. CD36 is a cell-...
Tamoxifen is an antiestrogen drug widely utilized for the adjuvant hormonal treatment of breast carcinoma. Its use in the primary prophylaxis of this disease is currently being proposed. Although the drug has few side effects, its precise action on breast tissue that has not undergone neoplastic transfor...
Os autores realizaram um estudo ultra-estrutural do epitélio vaginal de ratas, durante o estro pós-parto, sem e com tratamento prévio com tamoxifen. No grupo observaram a presença de epitélio bem desenvolvido constituído por duas regiöes epiteliais bem distintas: uma profunda, apresentado epitéli...
Os antiestrogênios podem ser utilizados atualmente como terapêutica adjuvante em pacientes acometidos pelo câncer de mama. É apresentada uma revisäo dos principais aspectos e das características farmacológicas e clínicas dos antiestrogênios ...
