BACKGROUND: The testes are highly susceptible to the adverse effects of chemotherapy and radiation at all stages of life. Exposure to these threats mainly occurs during cancer treatment and as an occupational hazard in radiation centers. The present study investigated the regenerative ability of adipose-...
Azoospermia/inducido químicamente,
Azoospermia/metabolismo,
Azoospermia/patología,
Células Madre Mesenquimatosas,
Antioxidantes/farmacología,
Cisplatino/efectos adversos,
Estrés Oxidativo,
Semen,
Espermatozoides/metabolismo,
Espermatozoides/patología,
Testículo/metabolismo,
Testosterona/farmacología
ABSTRACT We report a 27 -year-old male referred because of hypergonadotropic hypogonadism with low testosterone and azoospermia. At 23 years of age, he underwent an excision of a hypoechoic 0.7 cm nodule of the left testicle. The pathological diagnosis was a Leydig cell tumor. In the right testicle, ther...
BACKGROUND: Familial hyperaldosteronism type I is caused by the generation of a chimeric aldosterone synthase enzyme (ASCE) which is regulated by ACTH instead of angiotensin II. We have reported that in vitro, the wild-type (ASWT) and chimeric aldosterone synthase (ASCE) enzymes are inhibited by progeste...
Troncoso, Mayarling Francisca;
Pavez, Mario;
Wilson, Carlos;
Lagos, Daniel;
Duran, Javier;
Ramos, Sebastián;
Barrientos, Genaro;
Silva, Patricio;
Llanos, Paola;
Basualto-Alarcón, Carla;
Westenbrink, B. Daan;
Lavandero, Sergio;
Estrada, Manuel.
BACKGROUND: Testosterone regulates nutrient and energy balance to maintain protein synthesis and metabolism in cardiomyocytes, but supraphysiological concentrations induce cardiac hypertrophy. Previously, we determined that testosterone increased glucose uptake—via AMP-activated protein kinase (AMPK)...
Las mujeres han sido tratadas por décadas con testosterona intentando aliviar una gran variedad de síntomas con riesgos y beneficios inciertos.
En la mayoría de los países, la testosterona se prescribe “off-label”, de modo que las mujeres están utilizando compuestos y dosis ideadas para tratamie...
Andrógenos/fisiología,
Anfetaminas/efectos adversos,
Antagonistas Colinérgicos/efectos adversos,
Antagonistas de Andrógenos/efectos adversos,
Antagonistas de los Receptores Histamínicos/efectos adversos,
Anticonceptivos Orales/efectos adversos,
Cetoconazol/efectos adversos,
Consenso,
Danazol/efectos adversos,
Depresores del Apetito/efectos adversos,
Disfunciones Sexuales Psicológicas/etiología,
Disfunciones Sexuales Psicológicas/terapia,
Ensayos Clínicos Controlados como Asunto,
Fármacos Cardiovasculares/efectos adversos,
Fenitoína/efectos adversos,
Hormona Liberadora de Gonadotropina/efectos adversos,
Indometacina/efectos adversos,
Inhibidores de la Aromatasa/efectos adversos,
Inhibidores del Factor Xa/efectos adversos,
Narcóticos/efectos adversos,
Placebos/administración & dosificación,
Posmenopausia/efectos de los fármacos,
Posmenopausia/fisiología,
Psicotrópicos/efectos adversos,
Tamoxifeno/efectos adversos,
Testosterona/administración & dosificación,
Testosterona/análisis,
Testosterona/efectos adversos,
Testosterona/farmacología,
Testosterona/uso terapéutico,
Uso Fuera de lo Indicado
Silva, Lorena Doretto da;
Veridiano, Juliana Mora;
Oliveira, Jussara Celi Conceição;
Sayeg, Anna Carolina Haddad;
Mader, Ana Maria Amaral Antonio;
Petri, Giuliana;
Bianco, Bianca;
Fernandes, César Eduardo;
Toledo, Olga Maria Szymanski de;
Pompei, Luciano de Melo;
Steiner, Marcelo Luis.
Abstract Objective The present article aims to evaluate the impact of testosterone treatment on the expansion of visceral, subcutaneous and intramedullary adipose tissue of ovariectomized rats and the visceral and subcutaneous fat expression of peroxisome proliferator-activated receptors (PPARs) gamma....
Abstract Objective To investigate the action of testosterone (T), isolated or associated with estradiol benzoate (EB), on the proliferation markers and apoptosis of breasts of ovariectomized rats. Methods A total of 48 castrated female Wistar rats were divided into 6 groups, and each of them were sub...
Apoptosis/efectos de los fármacos,
Biomarcadores/análisis,
Mama/citología,
Mama/patología,
Calcinosis/patología,
Caspasa 3/análisis,
Proliferación Celular/efectos de los fármacos,
Estradiol/análogos & derivados,
Estradiol/farmacología,
Ovariectomía,
Antígeno Nuclear de Célula en Proliferación/análisis,
Ratas Wistar,
Testosterona/farmacología
ABSTRACT Various studies have linked metformin, a universally antidiabetic drug, with semen quality; however, such a direct link has not been established. This review systematically addresses and summarizes the effect of metformin on semen quality, particularly sperm function. We searched the MEDLINE ele...
Abstract Background: Impaired angiogenesis in cardiac tissue is a major complication of diabetes. Protein kinase B (AKT) and extracellular signal regulated kinase (ERK) signaling pathways play important role during capillary-like network formation in angiogenesis process. Objectives: To determine the e...
Andrógenos/farmacología,
Andrógenos/uso terapéutico,
Diabetes Mellitus Experimental/metabolismo,
Diabetes Mellitus Experimental/fisiopatología,
Diabetes Mellitus Tipo 1/metabolismo,
Diabetes Mellitus Tipo 1/fisiopatología,
Ensayo de Inmunoadsorción Enzimática,
Quinasas MAP Reguladas por Señal Extracelular/análisis,
Quinasas MAP Reguladas por Señal Extracelular/efectos de los fármacos,
Quinasas MAP Reguladas por Señal Extracelular/metabolismo,
Corazón/efectos de los fármacos,
Corazón/fisiopatología,
Terapia de Reemplazo de Hormonas/métodos,
Miocardio/química,
Condicionamiento Físico Animal/fisiología,
Testosterona/farmacología,
Factores de Tiempo,
Ratas Wistar,
Reproducibilidad de los Resultados,
Transducción de Señal/efectos de los fármacos
Resumo O texto tem como proposta refletir sobre os usos do hormônio testosterona entre os homens transexuais, tendo como ponto central a relação com o cuidado em saúde. O objetivo é entender, a partir do uso de fármacos a base de testosterona, como eles transversalizam, interagem e reiteram os proc...
