The study was designed to investigate the effect of Coconut Oil on the levels of some liver and hematological parameters in carbon tetrachloride intoxicated rabbits. Also the antioxidant capacity of Coconut Oil for various concentrations was assessed on the basis of percent scavenging of (DPPH) free radi...
SUMMARY: Carbon tetrachloride (CCl4) is a manufactured chemical and does not occur naturally in the environment. CCl4 is a clear liquid that evaporates very easily. It has a sweet odor. CCl4 is toxic to the mammalian liver and is hepatocarcinogenic in both rats and mice. Rosemary (Rosmarinus Officinalis)...
Enfermedad Hepática Inducida por Sustancias y Drogas/tratamiento farmacológico,
Cinamatos/administración & dosificación,
Depsidos/administración & dosificación,
Antioxidantes/administración & dosificación,
Tetracloruro de Carbono/toxicidad,
Inmunohistoquímica,
Estrés Oxidativo/efectos de los fármacos,
Microscopía Electrónica de Transmisión,
Cinamatos/farmacología,
Depsidos/farmacología,
Antioxidantes/farmacología,
Malondialdehído/análisis,
Glutatión Peroxidasa/análisis,
Superóxido Dismutasa/análisis
Dunjić, Momir;
Krstić, Dejan;
Živković, Jovan;
Cvetković, Saša;
Dunjić, Katarina;
Mirković, Miloš;
Ranković, Goran;
Ranković, Branislava;
Sokolović, Danka;
Sokolović, Dušan.
Abstract Carbon tetrachloride (CCl4) represents an organic chemical that causes reactive oxygen species derived organ disturbances including male infertility. Melatonin (MLT) is a neurohormone with strong antioxidant capacity, involved in numerous physiological processes. In this study we evaluated the c...
The liver as an organ is important for the metabolism of drugs and toxins. However, it is not immune from environmental insults. Exposure of liver cells to carbon tetrachloride (CCl4) results in the generation of tricholoromethyl radicals, which induce liver toxicity. This study a...
O presente estudo avaliou a hepatotoxicidade induzida pelo CCl4 durante o efeito glicocorticoide da dexametasona (DEX) na fisiopatologia da reação inflamatória aguda em tilápias do Nilo, Oreochromis niloticus, correlacionando a funcionalidade hepática à cinética de acúmulo celular em aerocistite ...
Trachyspermum ammi (T. ammi) has been used in folk medicine as anti-inflammatory, antipyretic, antibacterial, antifungal agent. The present study was conducted to investigate the protective effect of Trachyspermum ammi (T. ammi) essential oil against CC14- induced nephrotoxicity in mice. Thirty-five mice...
Spirlandeli, Adriano L;
Dick-de-Paula, Ingrid;
Zamarioli, Ariane;
Jorgetti, Vanda;
Ramalho, Leandra NZ;
Nogueira-Barbosa, Marcello H;
Volpon, Jose B;
Jordão, Alceu A;
Cunha, Fernando Q;
Fukada, Sandra Y;
de Paula, Francisco JA.
OBJECTIVES: The present study was designed to evaluate the bone phenotypes and mechanisms involved in bone disorders associated with hepatic osteodystrophy. Hepatocellular disease was induced by carbon tetrachloride (CCl4). In addition, the effects of disodium pamidronate on bone tissue were evaluated. ...
Conservadores de la Densidad Ósea/farmacología,
Enfermedades Óseas Metabólicas/tratamiento farmacológico,
Enfermedades Óseas Metabólicas/etiología,
Enfermedades Óseas Metabólicas/metabolismo,
Remodelación Ósea/efectos de los fármacos,
Resorción Ósea/metabolismo,
Huesos/diagnóstico por imagen,
Huesos/efectos de los fármacos,
Huesos/metabolismo,
Tetracloruro de Carbono,
Subunidad alfa 1 del Factor de Unión al Sitio Principal/genética,
Difosfonatos/farmacología,
Modelos Animales de Enfermedad,
Cirrosis Hepática/inducido químicamente,
Cirrosis Hepática/metabolismo,
Hepatopatías/complicaciones,
Hepatopatías/metabolismo,
Ratones Endogámicos C57BL,
Osteoprotegerina/genética,
Fósforo/administración & dosificación,
Ligando RANK/genética,
Fosfatasa Ácida Tartratorresistente/genética,
Microtomografía por Rayos X
Introducción: las plantas medicinales han sido utilizadas con fines terapéuticos desde tiempos antiguos sobre diversas enfermedades, en este sentido, se han reportado por la medicina tradicional una gran variedad de plantas con actividad gastrointestinal y efecto hepatoprotector. Las plantas utilizadas...
O óleo da amêndoa de pequi (Caryocar brasiliense Camb.) é considerado um coproduto do fruto, consumido na região do Cerrado, bioma brasileiro. Ele é fundamental para agregar valor e ampliar a utilização deste fruto regional a outros setores produtivos comerciais. Relatos na literatura apontam que ...
BACKGROUND: To evaluate the hepatoprotective potential and invitro cytotoxicity studies of whole plant methanol extract of Rumex vesicarius L. Methanol extract at a dose of 100 mg/kg bw and 200 mg/kg bw were assessed for its hepatoprotective potential against CCl4-induced hepatotoxicity by monitoring act...
Proliferación Celular/efectos de los fármacos,
Enfermedad Hepática Inducida por Sustancias y Drogas/tratamiento farmacológico,
Citotoxinas/farmacología,
Fitoterapia/métodos,
Extractos Vegetales/farmacología,
Rumex/química,
Alanina Transaminasa/metabolismo,
Fosfatasa Alcalina/metabolismo,
Anticarcinógenos/farmacología,
Antioxidantes/metabolismo,
Antioxidantes/farmacología,
Aspartato Aminotransferasas/metabolismo,
Bilirrubina/metabolismo,
Catalasa/metabolismo,
Enfermedad Hepática Inducida por Sustancias y Drogas/metabolismo,
Enfermedad Hepática Inducida por Sustancias y Drogas/patología,
Ingestión de Líquidos/efectos de los fármacos,
Ingestión de Alimentos/efectos de los fármacos,
Hígado/efectos de los fármacos,
Hígado/metabolismo,
Malondialdehído/metabolismo,
Silimarina/farmacología,
Superóxido Dismutasa/metabolismo,
Tetracloruro de Carbono,
Formazáns,
Células Hep G2,
Metanol,
Ratas Wistar,
Sales de Tetrazolio
