Home > LILACS - Literatura Latinoamericana y del Caribe de Ciencias de la Salud > Search result

Results: 3

Molecular variation of Plasmodium vivax dehydrofolate reductase in Mexico and Nicaragua contrasts with that occurring in South America

González-Cerón, Lilia; Rodríguez, Mario H; Montoya, Alberto; Santillán-Valenzuela, Frida; Corzo-Gómez, Josselin C.
Salud pública Méx; 62 (4), 2020
Abstract: Objective: To research mutations associated to pyrimethamine resistance in dihydrofolate reductase (pvdhfr) of Plasmodium vivax from Mexico and Nicaragua and compare it to that reported in the rest of America. Materials and methods: Genomic DNA was obtained from P. vivax-infected blood samp...
Variación Genética, Plasmodium vivax/genética, Tetrahidrofolato Deshidrogenasa/genética, Antiprotozoarios/farmacología, Brasil, Colombia, Guyana Francesa, Honduras, Resistencia a los Insecticidas/genética, México, Mutación, Nicaragua, Plasmodium vivax/enzimología, Pirimetamina/farmacología, América del Sur
Fulltext

Otimização de novos inibidores da di-idrofolato redutase de Mycobaterium tuberculosis (mtDHFR): Docking molecular, sí­ntese, avaliação da inibição enzimática e da atividade antimicobacte

Souza, Alfredo Danilo Ferreira de.
A tuberculose (TB) é considerada uma das principais doenças infecciosas e apresenta fatores críticos como a relação com o HIV/AIDS, tratamento longo e a resistência a múltiplos fármacos. A enzima di-hidrofolato redutase das micobactérias (mtDHFR) é um alvo pouco explorado e apresenta grande pot...
Optimización de Procesos, Mycobacterium/clasificación, Tuberculosis/patología, Tetrahidrofolato Deshidrogenasa/análisis, Simulación del Acoplamiento Molecular/instrumentación, Química Farmacéutica/métodos
Fulltext

Status of dhps and dhfr genes of Plasmodium falciparum in Colombia before artemisinin based treatment policy

Villa, Andrés; Carmona-Fonseca, Jaime; Benito, Agustín; Martínez, Alonso; Maestre, Amanda.
Infectio; 16 (1), 2012
Introduction: Surveillance of the genetic characteristics of dhps and dhfr can be useful to outline guidelines for application of intermittent preventive therapy in Northwest Colombia and to define the future use of antifolates in artemisinin-based combination therapy schemes. Objective: To evaluate the ...
Plasmodium falciparum, Malaria, Sulfadoxina, Tetrahidrofolato Deshidrogenasa, Dihidropteroato Sintasa, Colombia, Artemisininas
Fulltext