Characterisation of the in vitro activity of a Nitazoxanide-N-methyl-1H-benzimidazole hybrid molecule against albendazole and nitazoxanide susceptible and resistant strains of Giardia intestinalis and its in vivo giardicidal activity
Mem. Inst. Oswaldo Cruz; 115 (), 2020
BACKGROUND It was previously demonstrated that CMC-20, a nitazoxanide and N-methyl-1H-benzimidazole hybrid molecule, had higher in vitro activity against Giardia intestinalis WB strain than metronidazole and albendazole and similar to nitazoxanide. OBJETIVES To evaluate the in vitro activity of CMC-20...
Albendazol/química, Albendazol/farmacología, Antiprotozoarios/química, Antiprotozoarios/farmacología, Proteínas del Citoesqueleto/efectos de los fármacos, Técnica del Anticuerpo Fluorescente Indirecta, Giardia lamblia/efectos de los fármacos, Pruebas de Sensibilidad Parasitaria, Tiazoles/química, Tiazoles/farmacología, Factores de Tiempo