SUMMARY: The response of the immune system to harmful stimuli leads to inflammation, and the adverse effects of the toxic hepatitis chemical, thioacetamide (TAA) on the human body are well documented. This article investigated the degree of protection provided by the combined pleotropic drug, metformin (...
Metformina/farmacología,
Resveratrol/farmacología,
Tioacetamida/toxicidad,
Cirrosis Hepática/inducido químicamente,
Serina-Treonina Quinasas TOR,
Inflamación,
Factor de Necrosis Tumoral alfa,
Citocinas/antagonistas & inhibidores,
Sirolimus,
Inmunohistoquímica,
Hígado/efectos de los fármacos,
Inhibidor Tisular de Metaloproteinasa-1,
Cirrosis Hepática/tratamiento farmacológico
SUMMARY: The toxic effects of thioacetamide (TAA) and carbon tetrachloride on the human body are well recognized. In this study, we examined whether TAA intoxication can induce kidney leukocyte infiltration (measured as leukocyte common antigen CD45) associated with the augmentation of the reactive oxyge...
Metformina/uso terapéutico,
Lesión Renal Aguda/tratamiento farmacológico,
Lesión Renal Aguda/inducido químicamente,
Tioacetamida/toxicidad,
Hipoglucemiantes/uso terapéutico,
Especies Reactivas de Oxígeno,
Antígenos Comunes de Leucocito,
Factor de Necrosis Tumoral alfa,
Inflamación,
Inmunohistoquímica,
Biomarcadores
SUMMARY: Liver transplantation is the only available method to treat liver failure induced by chronic liver injury. We sought to determine whether the angiotensin-converting enzyme inhibitor, captopril, can inhibit the development of chronic liver injury induced by the hepatotoxic agent thioacetamide (TA...
Captopril/administración & dosificación,
Enfermedad Hepática Inducida por Sustancias y Drogas/tratamiento farmacológico,
Tioacetamida/toxicidad,
Inflamación,
Factor Nuclear 1-alfa del Hepatocito,
Modelos Animales de Enfermedad,
Inmunohistoquímica,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Factor de Necrosis Tumoral alfa,
Inhibidores de la Metaloproteinasa de la Matriz,
Actinas,
Western Blotting,
Hígado/efectos de los fármacos,
Inhibidor Tisular de Metaloproteinasa-1,
Metaloproteinasa 9 de la Matriz,
Fibrosis
SUMMARY: This study aimed to investigate the changes in testis tissue of thioacetamide-induced rats and the effect of melatonin on these changes. Thirty-five male Wistar Albino rats were divided into five groups. Group I; Control (n=7), Group II; Melatonin (Mel) (10 mg/kg) a single dose (i.p)(n=7), Group...
Melatonina/farmacología,
Testículo/efectos de los fármacos,
Tioacetamida/toxicidad,
Ratas Wistar,
Proteínas de Choque Térmico/metabolismo,
Inmunohistoquímica,
Ensayo de Inmunoadsorción Enzimática,
Proteínas de Choque Térmico/efectos de los fármacos,
Melatonina/administración & dosificación,
Antioxidantes/farmacología,
Antioxidantes/administración & dosificación
Chronic hepatotoxicity is a debilitating and frequently life-threatening disease resulting in progressive liver failure. The toxic chemical, thioacetamide (TAA) is used to evaluate hepatoprotective agents, and the polyphenolic compound, resveratrol was proposed as a novel treatment for diseases with hype...
SUMMARY: Reproductive dysfunction is a complication for many diseases and toxins. Its early diagnosis and treatment are immensely important. Here the morphological histoarchitecture changes in early testicular and cauda toxicity before and after treatment with angiotensin receptor blockers were evaluated...
Losartán/farmacología,
Bencimidazoles/farmacología,
Tetrazoles/farmacología,
Bloqueadores del Receptor Tipo 1 de Angiotensina II/farmacología,
Testículo/efectos de los fármacos,
Tioacetamida/toxicidad,
Inmunohistoquímica,
Testosterona/análisis,
Ratas Sprague-Dawley,
Antígeno Nuclear de Célula en Proliferación/metabolismo,
Caspasa 3/metabolismo,
Testículo/patología,
Malondialdehído/análisis,
Glutatión/análisis
Potent heptatotoxic chemicals such as carbon tetrachloride and thioacetamide (TAA) are used to evaluate hepatoprotective agents. Here we sought to investigate the potential protective effect of the antidiabetic and antioxidant drug, metformin against liver injury induced by TAA. Model group rats received...
Thioacetamide (TAA) is one of the common fungicidal agents that induce liver injury varying from inflammation, necrosis, and fibrosis to cirrhosis. Many recent studies reported the beneficial effect of probiotics and silymarin on hepatotoxicity regardless the causative agents. Therefore, the present stud...
Thioacetamide (TAA) can induce various types of cirrhosis in the rat, including bridging fibrosis, biliary fibrosis, perisinusoidal/pericellular fibrosis and centrilobular fibrosis, in which different populations of hepatic myofibroblasts (MFs) are involved. The hepatic MFs can be classified into 3 group...
