Biological activity of synthesized 5-{1-[(4-chlorophenyl)sulfonyl]piperidin-4-yl}-2-mercapto-1, 3, 4-oxadiazole derivatives demonstrated by in silico and BSA binding studies
Braz. J. Pharm. Sci. (Online); 56 (), 2020
We synthesized a series of compounds bearing pharmacologically important 1,3,4-oxadiazole and piperidine moieties. Spectral data analysis by 1H-NMR, 13C-NMR, IR and EI-MS was used to elucidate the structures of the synthesized molecules. Docking studies explained the different types of interaction of the...
Simulación por Computador/clasificación, Sulfonamidas/efectos adversos, Aminoácidos/antagonistas & inhibidores, Análisis de Datos, Concentración 50 Inhibidora, Bacillus subtilis/clasificación, Espectroscopía de Protones por Resonancia Magnética/métodos, Inhibidores de la Colinesterasa/farmacología, Preparaciones Farmacéuticas/administración & dosificación, Salmonella typhi/clasificación, Albúmina Sérica Bovina, Ureasa, Tiourea