Results: 8

Changes of tyrosine phosphorylation in liver and kidney of polycystic ovarian rats induced by letrozole

Int. j. morphol; 38 (4), 2020
Letrozole (Letro) is a drug commonly used for breast cancer treatment since it can decrease estrogen level. In experimental animal, the Letro has been used to induce the polycystic ovarian syndrome (PCOS) model. Tyrosine phosphorylation (TyrPho) is an essential process in various biological functions bot...

Fenilcetonuria de diagnóstico precoz: Bases fisiopatológicas del daño neuronal y opciones terapéuticas
Early diagnosis of phenylketonuria. Physiopathology of the neuronal damage and therapeutic options

Medicina (B.Aires); 79 (supl.3), 2019
La fenilcetonuria, también conocida como PKU, es el error congénito más frecuente del metabolismo de los aminoácidos. La forma grave o PKU clásica no tratada, causa una discapacidad intelectual, aunque los programas de detección en el período neonatal, el diagnóstico y el tratamiento evitan la ap...

Localization and changes of tyrosine phosphorylated proteins and ß actin in epididymis of rats treated with valproic acid

Int. j. morphol; 36 (3), 2018
Tyrosine phosphorylated proteins have been localized and identified in male reproductive tissues such as testis and capacitated/ acrosome reacted sperm except epididymis. The changes of such proteins are associated with decreased sperm quality of valproic acid treatment. This study aimed to investigate t...

Localization and identification of tyrosine phosphorylated proteins in adult Sprague-Dawley rat testis

Int. j. morphol; 35 (4), 2017
SUMMARY: Spermatogenesis is a major process in testis occurring from puberty through life span of males. The tyrosine phosphorylation is assumed to play roles in spermatogenesis because this process is important for cell proliferations, divisions, and differentiations. However, the localizations and iden...

Putative 3-nitrotyrosine detoxifying genes identified in the yeast Debaryomyces hansenii: in silico search of regulatory sequences responsive to salt and nitrogen stress

Background: During salt stress, the yeast Debaryomyces hansenii synthesizes tyrosine as a strategy to avoid the oxidation of proteins. Tyrosine reacts with nitrogen radicals to form 3-nitrotyrosine. 3-nitrotyrosine prevents the effects of associated oxidative stress and thus contributes to the high halot...

Strong renal expression of heat shock protein 70, high mobility group box 1, inducible nitric oxide synthase, and nitrotyrosine in mice model of severe malaria

Abstract INTRODUCTION Renal damage is a consequence of severe malaria, and is generally caused by sequestration of Plasmodium falciparum -infected erythrocytes in the renal microcirculation, which leads to obstruction, hypoxia, and ischemia. This triggers high mobility group box 1 (HMGB1) to send a dang...

Myostatin promotes distinct responses on protein metabolism of skeletal and cardiac muscle fibers of rodents

Braz. j. med. biol. res; 50 (12), 2017
Myostatin is a novel negative regulator of skeletal muscle mass. Myostatin expression is also found in heart in a much less extent, but it can be upregulated in pathological conditions, such as heart failure. Myostatin may be involved in inhibiting protein synthesis and/or increasing protein degradation ...

¿Qué debe saber el pediatra de las hiperfenilalaninemias?

Rev. chil. pediatr; 86 (3), 2015
Las hiperfenilalaninemias se definen por un nivel sanguíneo de fenilalanina sobre 2 mg/dl. La principal causa es una mutación en el gen que codifica la fenilalanina hidroxilasa que cataliza la reacción que transforma la fenilalanina en tirosina. Las hiperfenilalaninemias se clasifican en benignas o le...