LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Propranolol inhibits myocardial infarction-induced brown adipose tissue D2 activation and maintains a low thyroid hormone state in rats

Seara, F A C; Araujo, I G; Império, G E; Marassi, M P; Silva, A C M; Mecawi, A S; Reis, L C; Olivares, E L.

Braz. j. med. biol. res; 52 (10), 2019

Considering the recognized role of thyroid hormones on the cardiovascular system during health and disease, we hypothesized that type 2 deiodinase (D2) activity, the main activation pathway of thyroxine (T4)-to-triiodothyronine (T3), could be an important site to modulate thyroid hormone status, which wo...

Tejido Adiposo Pardo/efectos de los fármacos, Tejido Adiposo Pardo/metabolismo, Agonistas Adrenérgicos beta/administración & dosificación, Modelos Animales de Enfermedad, Yoduro Peroxidasa/efectos de los fármacos, Yoduro Peroxidasa/metabolismo, Infarto del Miocardio/metabolismo, Propranolol/administración & dosificación, Ratas Wistar, Tiroxina/sangre, Tiroxina/efectos de los fármacos, Triyodotironina/sangre, Triyodotironina/efectos de los fármacos

Fulltext

Alterations of the rat thyroid gland under experimental conditions

The thiyroid gland of rats, was studied under experimental conditions porvided by administration of several doses of lithium carbonate. It was noted a drug a cumulative effcct on the serum; and the decrease of T3 and T4 hormones in the blood, as well as, the red blood cells, hemoglobin, hematocrit platel...