Com base nas perturbações fosfoproteômicas de moléculas associadas ao ciclo celular em células infectadas pelo coronavírus causador da síndrome respiratória aguda grave (SARSCoV)-2, a hipótese de inibidores do ciclo celular como uma terapia potencial para a doença de coronavírus 2019 (COVID-19...
Ciclo Celular/inmunología,
Pacientes/clasificación,
COVID-19/patología,
Proteoma/análisis,
Espectrometría de Masas/métodos,
Transcriptoma/inmunología,
Análisis de Secuencia de ARN/instrumentación,
Coronavirus/patogenicidad,
Cromosomas/metabolismo,
Células Asesinas Naturales/clasificación,
Enfermedades Respiratorias/patología,
d0188440,
d0123130,
ddcs0500220,
d0454730,
d0127200
Purpose: To investigate the role and mechanism of β1,3-N-acetylglucosaminyltransferase-3 gene (B3GNT3) in esophageal cancer (ESCA). Methods: The starBase database was used to evaluate the expression of B3GNT3. B3GNT3 function was measured using KYSE-30 and KYSE-410 cells of esophageal squamous cell carc...
BACKGROUND: Drought stress has significantly hampered agricultural productivity worldwide and can also result in modifications to DNA methylation levels. However, the dynamics of DNA methylation and its association with the changes in gene transcription and alternative splicing (AS) under drought stress ...
Fruit ripening is a biochemical process that results in flavor, odor, texture, and color suitable for human consumption, in addition to providing access to important nutrients. Although ripening promotes sensory and nutritional increases in fruits, there is also an increased susceptibility to physical da...
BACKGROUND: Scavenger receptor class B (SRB) is a multifunctional protein in animals that participates in physiological processes, including recognition of a wide range of ligands. Astaxanthin is a major carotenoid found in shrimp. However, the molecular mechanism of astaxanthin and SRB protein binding h...
Receptores Depuradores/genética,
Receptores Depuradores/metabolismo,
Penaeidae,
Receptores Depuradores/aislamiento & purificación,
Cromatografía Líquida de Alta Presión,
Xantófilas,
Transcriptoma,
Western Blotting,
Técnicas In Vitro,
Reacción en Cadena en Tiempo Real de la Polimerasa/métodos,
Alineación de Secuencia
Zhao, Lina;
Yang, Xi;
Feng, Chun;
Wang, Yue;
Wang, Qing;
Pei, Jiahong;
Wu, Jinting;
Li, Shuaiying;
Zhang, Honglei;
Cao, Xianbao.
BACKGROUND: Cross talk of tumor–immune cells at the gene expression level has been an area of intense research. However, it is largely unknown at the alternative splicing level which has been found to play important roles in the tumor–immune microenvironment. RESULTS: Here, we re-exploited one transc...
Hajrah, Nahid H;
Rabah, Samar O;
Alghamdi, Mohammed K;
Atef, Ahmed;
Edris, Sherif;
Alhebshi, Alawiah M;
Hassan, Sabah M;
Alzahrani, Dhafer A;
Bahieldin, Ahmed;
Mutwakil, Mohammed HZ;
Alqurashi, Yaser E;
Al-Zahrani, Hassan S;
Abo-Aba, Salah EM;
Jansen, Robert K;
Sabir, Jamal SM;
Hall, Neil;
Rasool Kamli, Majid.
BACKGROUND: Jasmonic acid (JA) is a signal transducer molecule that plays an important role in plant development and stress response; it can also efficiently stimulate secondary metabolism in plant cells. RESULTS: RNA-Seq technology was applied to identify differentially expressed genes and study the tim...
Immune-mediated inflammation plays a key role in the pathology of abdominal aortic aneurysm (AAA). We aimed to use a computational approach to profile the immune infiltration patterns and related core genes in AAA samples based on the overexpression of gene signatures. The microarray datasets of AAA and ...
Abstract Hyperglycemia, a major characteristic of diabetes, is considered to play a vital role in diabetic complications. High glucose levels have been found to inhibit the mineralization of dental pulp cells. However, gene expression associated with this phenomenon has not yet been reported. This is imp...
This study aimed to explore gene expression profiles that drive malignancy from low- to high-grade head and neck carcinomas (HNC), as well as to analyze their correlations with survival. Gene expressions and clinical data of HNC were downloaded from the Gene Expression Omnibus (GEO) repository. The signi...
