LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Analysis of the endometrial transcriptome at the time of implantation in women receiving a single post-ovulatory dose of levonorgestrel or mifepristone

Abstract Background: Levonorgestrel (LNG) is a progesterone receptor agonist used in both regular and emergency hormonal contraception; however, its effects on the endometrium as a contraceptive remain widely unknown and under public debate. Objective: To analyze the effects of LNG or mifepristone (MFP...

Functional and transcriptomic characterization of carboplatin-resistant A2780 ovarian cancer cell line

Viscarra, Tamara; Buchegger, Kurt; Jofre, Ignacio; Riquelme, Ismael; Zanella, Louise; Abanto, Michel; Parker, Alyssa C; Piccolo, Stephen R; Roa, Juan Carlos; Ili, Carmen; Brebi, Priscilla.

Biol. Res; 52 (), 2019

BACKGROUND: Ovarian cancer is a significant cancer-related cause of death in women worldwide. The most used chemotherapeutic regimen is based on carboplatin (CBDCA). However, CBDCA resistance is the main obstacle to a better prognosis. An in vitro drug-resistant cell model would help in the understanding...

Antineoplásicos/farmacología, Carboplatino/farmacología, Resistencia a Antineoplásicos/genética, Regulación Neoplásica de la Expresión Génica/efectos de los fármacos, Neoplasias Ováricas/genética, Transcriptoma/efectos de los fármacos, Muerte Celular/efectos de los fármacos, Muerte Celular/genética, Neoplasias Ováricas/tratamiento farmacológico, Neoplasias Ováricas/patología, Transcriptoma/genética, Línea Celular Tumoral, Fenotipo, Análisis de Secuencia de ARN, Transducción de Señal

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